Loaded Recombinant Human CXCR4 (N-Fc) on Pro-A Biosensor, can bind Recombinant Human CXCL12 with an affinity constant of 8.4 uM as determined in BLI assay. (Regularly tested)

SDF-1 alpha/CXCL12 Protein, Human, Recombinant V2 is expressed in E. coli. The accession number is P48061.

Human

E. coli

TPAR1,TLSF,SDF-1α,SDF-1,SDF1,SCYB12,PBSF,IRH,chemokine (C-X-C motif) ligand 12

Lys22-Lys89

> 95% as determined by SDS-PAGE

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Stromal Cell-Derived Factor-1 (SDF-1) is a chemokine member of the intercrine family. SDF1 is expressed as five isoforms that differ only in the C terminal tail. SDF1α and SDF1β are identical except for the four residues present in the C-terminus of SDF1β but absent from SDF1α. SDF1 isoforms interact with CXCR4 and CXCR7 receptors on the cell surface, and can also bind syndecan4. SDF1 is known to influence lymphopoiesis, regulate patterning and cell number of neural progenitors, and promote angiogenesis. It also enhances the survival of myeloid progenitor cells.