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F-15599

Name: F-15599
Brand: TargetMol
SKU: T7281
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7281Cas No. 635323-95-4

F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist (Ki: 3.4 nM).

F-15599

😃Good

Purity: 98.72%

Catalog No. T7281Cas No. 635323-95-4

F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist (Ki: 3.4 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$328	In Stock	In Stock
50 mg	$529	In Stock	In Stock
100 mg	$795	-	In Stock
200 mg	$1,090	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$112	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.72%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist (Ki: 3.4 nM).
Targets&IC50	5-HT1A:3.4 nM(ki)
In vivo	F-15599 exerted very potent (ID50 = 0.095 and 0.0059 mg/kg, respectively) anti-aggressive effects in male WTG rats. At 4.5-fold higher dose ranges, the anti-aggressive effects were accompanied by concomitant motor inactivity and/or reduction of social engagement. Pretreatment with WAY-100635 counteracted the behavioural effects of both agonists[1].
Animal Research	F-15599 agonists were acutely administered intraperitoneally in aggressive resident male WTG rats confronting an intruder[1].

Chemical Properties

Molecular Weight	394.85
Formula	C₁₉H₂₁ClF₂N₄O
Cas No.	635323-95-4
Smiles	Cc1cnc(CNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Relative Density.	1.33 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (56.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5326 mL	12.6630 mL	25.3261 mL	126.6304 mL
5 mM	0.5065 mL	2.5326 mL	5.0652 mL	25.3261 mL
10 mM	0.2533 mL	1.2663 mL	2.5326 mL	12.6630 mL
20 mM	0.1266 mL	0.6332 mL	1.2663 mL	6.3315 mL
50 mM	0.0507 mL	0.2533 mL	0.5065 mL	2.5326 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc