IL-21 Protein, Human, Recombinant

Name: IL-21 Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPY-01963
Rating: 4.5 (1 reviews)

(Synonyms: Za11, interleukin 21, IL-21, CVID11) Copy Product Info

Synonyms: Za11, interleukin 21, IL-21, CVID11

Catalog No. TMPY-01963 Copy Product Info

IL-21 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.6 kDa and the accession number is Q9HBE4-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$68	7-10 days	7-10 days
10 µg	$108	-	In Stock
20 µg	$177	In Stock	In Stock
50 µg	$298	-	In Stock
100 µg	$447	-	In Stock
200 µg	$791	-	In Stock
500 µg	$1,670	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:SDS-PAGE: 96.2%; SEC-HPLC: 96.1%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its ability to induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is 0.4-2 ng/mL.
Description	IL-21 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.6 kDa and the accession number is Q9HBE4-1.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	Q9HBE4-1
Construction	A DNA sequence encoding the mature form of human IL-21 (Q9HBE4-1) (Gln30-Ser162) was expressed with an initial Met. Predicted N terminal: Met
Protein Purity	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. ,
Endotoxin	< 5 EU/mg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	Za11, interleukin 21, IL-21, CVID11
Research Background	IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

15.6 kDa (predicted); 17 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.