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Trastuzumab emtansine (Synonyms: Trastuzumab emtansine, T-DM1)
Catalog No. T36647 Copy Product Info
Purity: 98%
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Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody–drug conjugate that combines the HER2-targeted antitumor specificity of trastuzumab with the potent cytotoxic activity of the microtubule inhibitor DM1, Trastuzumab emtansine enables selective intracellular delivery of the cytotoxic payload to HER2-expressing cells and supporting translational and mechanistic research in advanced breast cancer models.
Trastuzumab emtansine
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Catalog No. T36647
Synonyms Trastuzumab emtansine, T-DM1
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody–drug conjugate that combines the HER2-targeted antitumor specificity of trastuzumab with the potent cytotoxic activity of the microtubule inhibitor DM1, Trastuzumab emtansine enables selective intracellular delivery of the cytotoxic payload to HER2-expressing cells and supporting translational and mechanistic research in advanced breast cancer models.
Cas No. 1018448-65-1
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $597 | - | In Stock | |
| 5 mg | $1,320 | - | In Stock | |
| 10 mg | $2,150 | - | In Stock | |
| 25 mg | $3,190 | - | In Stock | |
| 50 mg | $4,280 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98%
Appearance:Liquid
Color:Transparent
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| Description | Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody–drug conjugate that combines the HER2-targeted antitumor specificity of trastuzumab with the potent cytotoxic activity of the microtubule inhibitor DM1, Trastuzumab emtansine enables selective intracellular delivery of the cytotoxic payload to HER2-expressing cells and supporting translational and mechanistic research in advanced breast cancer models. |
| In vitro | Trastuzumab emtansine (2 μg/mL; 3 d) markedly inhibits the proliferation of epithelial ovarian cancer (EOC) cells[2]. |
| In vivo | Method: Trastuzumab emtansine was administered intravenously at 15 mg/kg three to five times weekly for 3 weeks in CB-17/SCID mice injected with OVA10 cells. Result: Trastuzumab emtansine produced significant antitumor effects in tumor-bearing mice[2]. |
| Synonyms | Trastuzumab emtansine, T-DM1 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Uniprot ID | |
| Target | HER2 |
| Formula | N/A |
| Cas No. | 1018448-65-1 |
| Smiles | [Trastuzumab emtansine] |
| Isotype | IgG1 |
| Storage | keep away from moisture,keep away from direct sunlight,store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: 160 mg/mL, Sonication is recommended. |
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