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Trastuzumab emtansine
😃Good
Catalog No. T36647Cas No. 1018448-65-1
Alias Trastuzumab emtansine, T-DM1
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody–drug conjugate that combines the HER2-targeted antitumor specificity of trastuzumab with the potent cytotoxic activity of the microtubule inhibitor DM1, Trastuzumab emtansine enables selective intracellular delivery of the cytotoxic payload to HER2-expressing cells and supporting translational and mechanistic research in advanced breast cancer models.
Trastuzumab emtansine
😃Good
Purity: 98%
Catalog No. T36647Alias Trastuzumab emtansine, T-DM1Cas No. 1018448-65-1
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody–drug conjugate that combines the HER2-targeted antitumor specificity of trastuzumab with the potent cytotoxic activity of the microtubule inhibitor DM1, Trastuzumab emtansine enables selective intracellular delivery of the cytotoxic payload to HER2-expressing cells and supporting translational and mechanistic research in advanced breast cancer models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $597 | - | In Stock | |
| 5 mg | $1,320 | - | In Stock | |
| 10 mg | $2,150 | - | In Stock | |
| 25 mg | $3,190 | - | In Stock | |
| 50 mg | $4,280 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98%
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Antibody Information
| Description | Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody–drug conjugate that combines the HER2-targeted antitumor specificity of trastuzumab with the potent cytotoxic activity of the microtubule inhibitor DM1, Trastuzumab emtansine enables selective intracellular delivery of the cytotoxic payload to HER2-expressing cells and supporting translational and mechanistic research in advanced breast cancer models. |
| In vitro | Trastuzumab emtansine (2 μg/mL; 3 d) markedly inhibits the proliferation of epithelial ovarian cancer (EOC) cells[2]. |
| In vivo | Method: Trastuzumab emtansine was administered intravenously at 15 mg/kg three to five times weekly for 3 weeks in CB-17/SCID mice injected with OVA10 cells. Result: Trastuzumab emtansine produced significant antitumor effects in tumor-bearing mice[2]. |
| Synonyms | Trastuzumab emtansine, T-DM1 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | ＜ 1.0 EU/mg |
| Uniprot ID | |
| Target | HER2 |
| Formula | N/A |
| Cas No. | 1018448-65-1 |
| Smiles | [Trastuzumab emtansine] |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | IgG1 |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight,store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: 160 mg/mL, Sonication is recommended. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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