Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

ATN-161

Name: ATN-161
Brand: TargetMol
SKU: T10398
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T10398Cas No. 262438-43-7

ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis. ATN-161 also suppresses spike protein interaction with integrin α5β1 and may be employed against SARS-CoV-2 infection.

ATN-161

Copy Product Info

😃Good

Catalog No. T10398Cas No. 262438-43-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$39	8-10 weeks	8-10 weeks
5 mg	$89	8-10 weeks	8-10 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis. ATN-161 also suppresses spike protein interaction with integrin α5β1 and may be employed against SARS-CoV-2 infection.
In vitro	Compared to the control group and monotherapy, ATN-161 combined with 5-FU significantly inhibited tumor cell proliferation and markedly increased the number of apoptotic (TUNEL-positive) tumor cells. In comparison to the control group, ATN-161 reduced endothelial cell (EC) counts by 21% after 48 hours of incubation [1]. ATN-161 was able to inhibit VEGF-induced migration of Homo sapiens corneal endothelial cells (hCECs) and the formation of capillary-like tubular structures, but showed no inhibitory effect on cell proliferation. Starting from a concentration of 100 nM, ATN-161 reduced VEGF-induced cell migration in a dose-dependent manner[2].
In vivo	In the α5β1-negative human colon cancer xenograft model (HT29), ATN-161 treatment significantly reduced tumor weight and vascular density [1]. Intravitreal injection of ATN-161 after laser photocoagulation effectively suppressed leakage and neovascularization of choroidal neovascularization (CNV), with efficacy comparable to that of AF564 [2].

Chemical Properties

Molecular Weight	597.64
Formula	C₂₃H₃₅N₉O₈S
Cas No.	262438-43-7
Smiles	C(N[C@@H](CC1=CN=CN1)C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N)=O)=O)CS)=O)CO)=O)(=O)[C@H]2N(C(C)=O)CCC2
Relative Density.	1.443 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (33.46 mM)

H2O: ≥ 8 mg/mL

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6732 mL	8.3662 mL	16.7325 mL	83.6624 mL
5 mM	0.3346 mL	1.6732 mL	3.3465 mL	16.7325 mL
10 mM	0.1673 mL	0.8366 mL	1.6732 mL	8.3662 mL
20 mM	0.0837 mL	0.4183 mL	0.8366 mL	4.1831 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc