Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MS78, an acetylation targeting chimera (AceTAC), specifically acetylates the p53Y220C mutant by recruiting the histone acetyltransferase p300/CBP. This compound enhances the expression of TRAIL apoptotic genes while concurrently suppressing DNA damage response pathways. Its structure comprises a CBP/p300 binding domain, a p53Y220C targeting moiety, and a connecting linker [1].
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Description | MS78, an acetylation targeting chimera (AceTAC), specifically acetylates the p53Y220C mutant by recruiting the histone acetyltransferase p300/CBP. This compound enhances the expression of TRAIL apoptotic genes while concurrently suppressing DNA damage response pathways. Its structure comprises a CBP/p300 binding domain, a p53Y220C targeting moiety, and a connecting linker [1]. |
Molecular Weight | 1024.25 |
Formula | C57H66FN9O6S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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