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Heptamidine
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Catalog No. T11553LCas No. 94345-47-8
Alias SBi4211
Heptamidine is an effective Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd: 6.9 μM). It selectively kills melanoma cells with S100B over those without S100B. It is a useful tool for the investigation of Myotonic dystrophy.
Heptamidine
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Catalog No. T11553LAlias SBi4211Cas No. 94345-47-8
Heptamidine is an effective Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd: 6.9 μM). It selectively kills melanoma cells with S100B over those without S100B. It is a useful tool for the investigation of Myotonic dystrophy.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Heptamidine is an effective Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd: 6.9 μM). It selectively kills melanoma cells with S100B over those without S100B. It is a useful tool for the investigation of Myotonic dystrophy. |
| Targets&IC50 | S100B:(kd)6.9 μM |
| In vitro | Heptamidine is a Pentamidine-S100B complex with two pentamidine molecules binding per monomer of S100B, acting as an inhibitor for S100B[1]. It rescues mis-splicing of minigene reporters in a HeLa cell DM1 model with an EC50 value of 15 μM. Compared to Propamidine and Pentamidine, Heptamidine (20 μM) does not significantly reduce CUG levels. It exhibits cytotoxicity at concentrations above 17.5 μM in HeLa cells expressing 960 CUG repeats[2]. |
| In vivo | Heptamidine (intraperitoneal injection; 20 or 30 mg/kg; 7 days) induces a dose-dependent reduction of exon 7a inclusion in HSALR mice, returning to wild-type levels (6±1%) at a 20 mg/kg dose. Myotonia is reduced from grade 3 to grade 1 (occasional myotonic discharge) or grade 0 at both 20 and 30 mg/kg [2]. |
| Synonyms | SBi4211 |
| Molecular Weight | 368.47 |
| Formula | C21H28N4O2 |
| Cas No. | 94345-47-8 |
| Smiles | O(CCCCCCCOC1=CC=C(C(=N)N)C=C1)C2=CC=C(C(=N)N)C=C2 |
| Relative Density. | 1.17 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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