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TargetMol | Compound Library

Wnt/Hedgehog/Notch Compound Library

Catalog No. L4300

The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development. Aberrant regulation of the Wnt signaling pathway is a prevalent theme in cancer biology. The Hedgehog (Hh) pathway is a major regulator of many fundamental processes in vertebrate embryonic development including stem cell maintenance, cell differentiation, tissue polarity and cell proliferation. Constitutive activation of the Hh pathway leading to tumorigenesis is seen in basal cell carcinomas and medulloblastoma. A variety of other human cancers, including brain, gastrointestinal, lung, breast and prostate cancers, also demonstrate inappropriate activation of this pathway. Targeting the Hh signaling pathway provides a new and exciting therapeutic option for a broad variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms. The Notch signaling cascade is critical for cell proliferation, differentiation, development and homeostasis. Deregulated Notch signaling is found in various diseases, such as T-cell leukemia, breast cancer, prostate cancer, colorectal cancer and lung cancer as well as central nervous system (CNS) malignancies, CADASIL, Alagille syndrome, spondylocostal dysostosis, etc. Wnt/Hedgehog/Notch Compound Library from TargetMol, a unique collection of 398 Wnt/Hedgehog/Notch signaling targeted compounds, can be used for research in Wnt/Hedgehog/Notch signaling and related drug screening (high throughput and high content screening).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L4300

Wnt/Hedgehog/Notch Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 398 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Wnt/beta-catenin
PKC
GSK-3
Apoptosis
Hedgehog/Smoothened
Autophagy
Smo
ROCK
CDK
PKA
c-Myc
Endogenous Metabolite
Gamma-secretase
Antibacterial
PARP
Akt
ERK
Antibiotic
Porcupine
Bcl-2 Family
Parasite
S6 Kinase
Antifungal
NF-κB
Serine/threonin kinase
Src
Casein Kinase
Calcium Channel
VEGFR
MAPK
Reactive Oxygen Species
Virus Protease
HIV Protease
Estrogen Receptor/ERR
Epigenetic Reader Domain
CaMK
COX
Beta Amyloid
Mitophagy
AMPK
Molecular Glues
FLT
Syk
PI3K
Topoisomerase
DYRK
Lipoxygenase
Estrogen/progestogen Receptor
Caspase
Drug Metabolite
Influenza Virus
Tyrosine Kinases
PDGFR
JNK
Myosin
TRP/TRPV Channel
Cytochromes P450
Lipid
Antiviral
STAT
5-HT Receptor
SGK
PPAR
Chk
Potassium Channel
Phosphatase
LDL
CXCR
p53
NO Synthase
gp120/CD4
EGFR
Aurora Kinase
FGFR
Microtubule Associated
Carbonic Anhydrase
HSV
mTOR
DHFR
p38 MAPK
RAAS
Cholecystokinin Receptor
Glucosidase
JAK
TGF-beta/Smad
Acyltransferase
IκB/IKK
AChR
Dehydrogenase
YAP
Pim
Glucocorticoid Receptor
GRK
Telomerase
DNA/RNA Synthesis
MEK
c-Kit
Monoamine Oxidase
Serine Protease
LIM Kinase
IL Receptor
Angiotensin-converting Enzyme (ACE)
KLF
HIF/HIF Prolyl-Hydroxylase
S1P Receptor
HCV Protease
Aryl Hydrocarbon Receptor
PDE
Cadherin
OXPHOS
Prostaglandin Receptor
Nrf2
Arginase
Ferroptosis
GTPase
PAK
Histone Acetyltransferase
Reverse Transcriptase
GABA Receptor
TNF
Sodium Channel
Adenylyl Cyclase
Dopamine Receptor
Bcr-Abl
Antifection
Survivin
Methionine Adenosyltransferase (MAT)
DAPK
ATPase
Antioxidant
Nucleoside Antimetabolite/Analog
ABC Transporter
GluR
IGF-1R
ATP Citrate Lyase
cGAS
Hippo pathway
HDAC
Hydroxylase
BTK

Keywords