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ADG-106

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Catalog No. T9901A-773

ADG-106 is a fully human agonistic monoclonal IgG4 antibody targeting CD137 (4-1BB). It activates CD137 through a potent FcγRIIB-mediated cross-linking mechanism while antagonizing the CD137 ligand. The isotype control for ADG-106 can be referred to as HumanIgG4(S228P) kappa, Isotype Control.

ADG-106

ADG-106

😃Good
Catalog No. T9901A-773
ADG-106 is a fully human agonistic monoclonal IgG4 antibody targeting CD137 (4-1BB). It activates CD137 through a potent FcγRIIB-mediated cross-linking mechanism while antagonizing the CD137 ligand. The isotype control for ADG-106 can be referred to as HumanIgG4(S228P) kappa, Isotype Control.
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Product Introduction

Bioactivity
Description
ADG-106 is a fully human agonistic monoclonal IgG4 antibody targeting CD137 (4-1BB). It activates CD137 through a potent FcγRIIB-mediated cross-linking mechanism while antagonizing the CD137 ligand. The isotype control for ADG-106 can be referred to as HumanIgG4(S228P) kappa, Isotype Control.
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Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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