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cis-4-Hydroxy-L-proline

Name: cis-4-Hydroxy-L-proline
Brand: TargetMol
SKU: T37512
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T37512Cas No. 618-27-9

cis-4-Hydroxy-L-proline is an inhibitor of the synthesis and extracellular deposition of collagen. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer.

cis-4-Hydroxy-L-proline

🥰Excellent

Purity: 99.88%

Catalog No. T37512Cas No. 618-27-9

Pack Size	Price	Availability
200 mg	$33	In Stock
500 mg	$55	In Stock
1 g	$79	In Stock
5 g	$193	In Stock

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Batch Information

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Purity:99.88%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	cis-4-Hydroxy-L-proline is an inhibitor of the synthesis and extracellular deposition of collagen. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer.
In vivo	cis-4-Hydroxy-L-proline depressed the growth of primary N-nitrosomethylurea-induced rat mammary tumors[4].

Chemical Properties

Molecular Weight	131.13
Formula	C₅H₉NO₃
Cas No.	618-27-9
Smiles	O[C@@H]1CN[C@@H](C1)C(O)=O
Relative Density.	1.3121 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (762.6 mM), Sonication is recommended.

DMSO: Soluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	7.6260 mL	38.1301 mL	76.2602 mL	381.3010 mL
5 mM	1.5252 mL	7.6260 mL	15.2520 mL	76.2602 mL
10 mM	0.7626 mL	3.8130 mL	7.6260 mL	38.1301 mL
20 mM	0.3813 mL	1.9065 mL	3.8130 mL	19.0650 mL
50 mM	0.1525 mL	0.7626 mL	1.5252 mL	7.6260 mL
100 mM	0.0763 mL	0.3813 mL	0.7626 mL	3.8130 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc