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Proteases/Proteasome Proteases/ProteasomeThrombin
Thrombin ( fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene. Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the clotting process. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions.
Heparin sodium salt
Cited
Sodium heparinate, Heparin sodium
T65319041-08-1
Heparin sodium is a sulfated polysaccharide, which belongs to the family of glycosaminoglycans. It is utilized as an anticoagulant and interacted with diverse proteins for numerous important biological activities.Heparin sodium salt (Sodium heparinate) significantly inhibits exosome-cell interactions.
- $41
Size
QTY
CitedHeparin Cited
Dalteparin, Certoparin, Bemiparin, Adomiparin
T206549005-49-6
Heparin (Adomiparin) is a mucopolysaccharide sulfate often used as an anticoagulant in clinical medicine.Heparin has shown partial anti-inflammatory activity in in vivo experiments.
- $66
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QTY
CitedUK-396082
UK-396,082
T69294400044-47-5In house
UK-396082 is a thrombin-activated fibrinolysis inhibitor (TAFI) that inhibits Carboxypeptidase B. It is used in the study of thrombosis, atherosclerosis, cancer, and fibrotic conditions.
- $333
Size
QTY
Melagatran
T11994159776-70-2In house
Melagatran is an orally available, direct synthetic thrombin inhibitor that does not require endogenous cofactors other than thrombin and does not significantly interact with any other enzymes in the coagulation cascade or with the fibrinolytic enzymes.
- $540
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QTY
Flovagatran
TGN 255
T31806871576-03-3In house
Flovagatran (TGN 255) is an orally active, potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.
- $762
Size
QTY
Eltrombopag
SB-497115-GR, SB-497115
T2562496775-61-2
Eltrombopag (SB-497115-GR), an orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating activity, binds to and stimulates the platelet thrombopoietin receptor (TPO-R or CD110).
- $40
Size
QTY
Thrombin (MW 37kDa) Cited
T195809002-04-4
Thrombin (MW 37kDa) is an allosteric serine protease with trypsin-like activity.
- $139
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QTY
CitedH-Gly-Arg-pNA dihydrochloride
H-Gly-Arg-Pna 2HCl
T37034125455-61-0
H-Gly-Arg-pNA dihydrochloride (H-Gly-Arg-Pna 2HCl) belongs to the class of peptides that bind to 1,2 thrombin and can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity.
- $135
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QTY
Hirudin
Hirudin (54-65; non-sulfated)
T126366113274-56-9
Hirudin is a thrombin inhibitor that improves Gsdmd-mediated pyroptosis by inhibiting irf2. It can be used in research on diabetic nephropathy.
- $189
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QTY
AEBSF hydrochloride Cited
Pefabloc SC, AEBSF HCl
T637030827-99-7
AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.
- $30
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QTY
CitedDabigatran Cited
BIBR 953ZW, BIBR 953
T6295211914-51-1
Dabigatran (BIBR 953ZW) is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.
- $36
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QTY
CitedMenadione Cited
Vitamin K3
T044958-27-5
Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
- $31
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CitedEnoxaparin sodium
T22323679809-58-6
Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment myocardial infarction (STEMI), or STEMI with subsequent percutaneous coronary intervention (PCI)
- $31
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Avatrombopag Cited
YM477, E5501, AKR-501
T7417570406-98-3
Avatrombopag (YM477) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platelet production.
- $52
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CitedNQ301
T3757130089-98-4
NQ301, an antithrombotic agent, inhibits collagen-challenged rabbit platelet aggregation (IC50: 10 mg/mL).
- $53
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QTY
Argatroban Cited
MD-805, MCI-9038, Argipidine
T015574863-84-6
Argatroban is a specific thrombin inhibitor and a non-heparin anticoagulant that effectively prevents thrombus formation and is commonly used to establish thrombolysis models.
- $33
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CitedXimelagatran
H-37695, H37695, H 376-95, H 37695, H 376/95, EXANTA
T17265192939-46-1
Ximelagatran (H 376-95), a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active agent melagatran in vivo.
- $36
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Protamine sulfate
T410319009-65-8
Protamine sulfate is a polycationic peptide compound with anti-heparin activity. It can neutralize the anticoagulant effects of heparin, enhance lipid-mediated gene transfer, and is commonly used to establish cystitis models.
- $30
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Dermatan sulphate sodium
Chondroitin sulfate B sodium salt
T8473854328-33-5
Dermatan sulphate sodium (Chondroitin sulfate B sodium salt) is a linear sulfated polysaccharide, a glycosaminoglycan component of several important proteoglycans, and an activating ligand for the kinase of mesenchymal lymphoma. Dermatan sulphate sodium is an anticoagulant, inhibiting thrombus Dermatan sulphate sodium is an anticoagulant that inhibits thrombosis.
- $47
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QTY
Edoxaban Tosylate Monohydrate
edoxaban tosylate hydrate, DU-176b tosylate Monohydrate, DU-176b monohydrate
T23681229194-11-9
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
- $43
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Marstacimab
PF-6741086, PF6741086, PF-06741086, PF06741086
T818541985638-39-8
Marstacimab (PF-06741086) is a neutralizing antibody that binds to and inhibits inhibitors of the human tissue factor pathway. Marstacimab is an anti-tissue factor pathway inhibitor used in the study of hemophilia.
- $263
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QTY
Eltrombopag Olamine
SB-497115GR, SB497115, Revolade, Promacta Olamine, Eltrombopag diethanolamine salt
T6825496775-62-3
Eltrombopag Olamine (Eltrombopag diethanolamine salt) is an orally active small-molecule, nonpeptide thrombopoietin receptor agonist that stimulates megakaryopoiesis. It binds to and activates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), promoting the proliferation and differentiation of megakaryocytic cells and enhancing platelet production.
- $36
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QTY
Edoxaban
Lixiana
T2368L480449-70-5
Edoxaban (Lixiana) (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K i s of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and is able to be used for stroke prevention. Edoxaban is a also weak inhibitor of thrombin and factor IXaβ (FIXa), with K i s of 6.00 μM and 41.7 μM, respectively, exhibits >10 000-fold selectivity for FXa. Edoxaban has antithrombotic properties and is potential for thromboembolic diseases treatment [1] [2] [3].
- $45
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QTY
Argatroban Monohydrate
T22246141396-28-3
Argatroban Monohydrate is a selective thrombin inhibitor and a non-heparin anticoagulant that effectively prevents thrombosis. It is commonly used in thrombolysis model studies.
- $33
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