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PDpep1.3

🥰Excellent
Catalog No. TP3573Cas No. 2942277-55-4

PDpep1.3 is a peptide inhibitor targeting α-synuclein, which disrupts the direct interaction between α-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B). This disruption enables PDpep1.3 to restore the degradative functions of endosomes and lysosomes, reducing the levels and aggregation of α-synuclein, and safeguarding dopaminergic neurons from α-synuclein-induced degeneration. PDpep1.3 is useful for research on neurodegenerative diseases and protein-protein interactions.

PDpep1.3

PDpep1.3

🥰Excellent
Catalog No. TP3573Cas No. 2942277-55-4
PDpep1.3 is a peptide inhibitor targeting α-synuclein, which disrupts the direct interaction between α-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B). This disruption enables PDpep1.3 to restore the degradative functions of endosomes and lysosomes, reducing the levels and aggregation of α-synuclein, and safeguarding dopaminergic neurons from α-synuclein-induced degeneration. PDpep1.3 is useful for research on neurodegenerative diseases and protein-protein interactions.
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Product Introduction

Bioactivity
Description
PDpep1.3 is a peptide inhibitor targeting α-synuclein, which disrupts the direct interaction between α-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B). This disruption enables PDpep1.3 to restore the degradative functions of endosomes and lysosomes, reducing the levels and aggregation of α-synuclein, and safeguarding dopaminergic neurons from α-synuclein-induced degeneration. PDpep1.3 is useful for research on neurodegenerative diseases and protein-protein interactions.
Chemical Properties
Molecular Weight1400.53
FormulaC59H101N17O22
Cas No.2942277-55-4
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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