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Eribulin mesylate

Name: Eribulin mesylate
Brand: TargetMol
SKU: T13687
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: ER-086526 mesylate, E7389 mesylate, B1939 mesylate) Copy Product Info

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Synonyms: ER-086526 mesylate, E7389 mesylate, B1939 mesylate

Catalog No. T13687 Copy Product Info

Purity: 99.89%

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Eribulin mesylate (E7389 mesylate) belongs to natural product derivatives and is a microtubule-targeted anticancer agent, functioning as a microtubule dynamics inhibitor that suppresses tubulin polymerization through tubulin binding, with cell permeability. This drug is used for the treatment of metastatic breast cancer.

Cas No. 441045-17-6

Pack Size	Price	USA Stock	Global Stock
500 μg	$98	In Stock	In Stock
1 mg	$157	In Stock	In Stock
2 mg	$233	In Stock	In Stock
5 mg	$396	In Stock	In Stock
10 mg	$635	In Stock	In Stock
25 mg	$1,130	In Stock	In Stock
50 mg	$1,580	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.89%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Eribulin mesylate (E7389 mesylate) belongs to natural product derivatives and is a microtubule-targeted anticancer agent, functioning as a microtubule dynamics inhibitor that suppresses tubulin polymerization through tubulin binding, with cell permeability. This drug is used for the treatment of metastatic breast cancer.
Targets & IC50	LM8 cells:22.8 nM, MDA-MB-435 cells:0.09 nM, Dunn cells:21.5 nM
In vitro	Methods:Seventeen small cell lung cancer cell lines were incubated with 0–10 nM Eribulin mesylate for 5 days. In vitro activity was evaluated by MTS assay, flow cytometry, and Caspase-Glo 3/7 assay. Results: Eribulin mesylate concentration-dependently inhibited proliferation in all cell lines, with IC₅₀ values of 1–6 nM and inhibition rates of 53%–98% at 10 nM, while inducing G2/M phase arrest and apoptosis.[1] Methods: Human pancreatic cancer AsPC-1, Panc-1, SUIT-2 cells and human pancreatic endoderm hPE cells were used to evaluate Eribulin mesylate in vitro activity by WST assay (incubation concentration 0.5–10 ng/mL, treatment for 90 min) and morphological observation (treatment for 24 h). Results: Eribulin mesylate significantly and concentration-dependently inhibited viability of AsPC-1 and Panc-1 cells, inducing morphological changes including cell shrinkage and membrane blebbing, but had no effect on hPE cells.[2]
In vivo	Methods: Subcutaneous xenograft models of human leiomyosarcoma SK-LMS-1, liposarcoma SW 872, Ewing sarcoma A-673, and fibrosarcoma HT-1080 were established in Balb/c-nu mice. Eribulin mesylate was administered intravenously at doses of 0.875–3.5 mg/kg once every 7 days (q7d×1 or ×2), with normal saline as the control. Results: Eribulin mesylate demonstrated significant antitumor activity, with tumor regression observed in all models and good tolerability.[3]
Synonyms	ER-086526 mesylate, E7389 mesylate, B1939 mesylate

Chemical Properties

Molecular Weight	826
Formula	C₄₁H₆₃NO₁₄S
Cas No.	441045-17-6
Smiles	CS(O)(=O)=O.[H][C@@]12CC(=C)[C@]([H])(CC[C@@]3([H])C[C@@H](C)C(=C)[C@@]([H])(C[C@]4([H])O[C@H](C[C@H](O)CN)[C@H](OC)[C@@]4([H])CC(=O)C[C@@]4([H])CC[C@]5([H])O[C@@]6([H])[C@@]7([H])O[C@@]8(C[C@@]7([H])O[C@@]6([H])[C@@]([H])(O8)[C@@]5([H])O4)CC1)O3)O2
Relative Density.	no data available

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 98 mg/mL (118.64 mM), Sonication is recommended.

DMSO: 255 mg/mL (308.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (6.05 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2107 mL	6.0533 mL	12.1065 mL	60.5327 mL
5 mM	0.2421 mL	1.2107 mL	2.4213 mL	12.1065 mL
10 mM	0.1211 mL	0.6053 mL	1.2107 mL	6.0533 mL
20 mM	0.0605 mL	0.3027 mL	0.6053 mL	3.0266 mL
50 mM	0.0242 mL	0.1211 mL	0.2421 mL	1.2107 mL
100 mM	0.0121 mL	0.0605 mL	0.1211 mL	0.6053 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: Eribulin mesylate chemical structure | Eribulin mesylate in vivo | Eribulin mesylate in vitro | Eribulin mesylate formula | Eribulin mesylate molecular weight