Shopping Cart

Your shopping cart is currently empty

SEN177

Name: SEN177
Brand: TargetMol
SKU: T61063
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: SEN-177, SEN 177) Copy Product Info

🥰Excellent

Synonyms: SEN-177, SEN 177

Catalog No. T61063 Copy Product Info

Purity: 99.37%

🥰Excellent

SEN177 demonstrates potential utility in investigations involving Huntington’s disease and functions as a potent inhibitor of glutaminyl cyclase (QPCT), exhibiting an IC50 value of 0.013 μM for glutaminyl-peptide cyclotransferase-like (QPCTL). The Ki value of SEN177 for human glutaminyl cyclase (hQC) is 20 nM. SEN177 significantly reduces early-stage mutant HTT oligomerization and decreases the percentage of neurons containing Q80 aggregates. SEN177 is therefore relevant for neurodegenerative disease research, protein aggregation biology, and glutaminyl cyclase-associated molecular pathways.

Cas No. 2117405-13-5

Customer service consultation

Pack Size	Price	USA Stock	Global Stock
2 mg	$33	-	In Stock
5 mg	$51	-	In Stock
10 mg	$89	-	In Stock
25 mg	$148	-	In Stock
1 mL x 10 mM (in DMSO)	$56	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.37%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SEN177 demonstrates potential utility in investigations involving Huntington’s disease and functions as a potent inhibitor of glutaminyl cyclase (QPCT), exhibiting an IC50 value of 0.013 μM for glutaminyl-peptide cyclotransferase-like (QPCTL). The Ki value of SEN177 for human glutaminyl cyclase (hQC) is 20 nM. SEN177 significantly reduces early-stage mutant HTT oligomerization and decreases the percentage of neurons containing Q80 aggregates. SEN177 is therefore relevant for neurodegenerative disease research, protein aggregation biology, and glutaminyl cyclase-associated molecular pathways.
Targets & IC50	hQC:13nM
In vitro	SEN177 (0.08–50 μM, 0–96 h) results in dose-dependent reduction of SIRPα-FC (5μg/mL) binding in the breast cancer cell line MDA-MB-468[1]. SEN177 (10 μM, 72h) significantly enhances EGFR antibody-induced antibody-dependent cellular phagocytosis (ADCP) in esophageal squamous cell carcinoma cells (Kyse-30) and the breast cancer cell line MDA-MB-468[1]. SEN177 (50 μM, 24 h) decreases mutant HTT aggregate ratio and apoptosis in HeLa cells expressing HTT (Q74)[2].
Synonyms	SEN-177, SEN 177

Chemical Properties

Molecular Weight	338.38
Formula	C₁₈H₁₉FN₆
Cas No.	2117405-13-5
Smiles	FC=1N=CC(=CC1)C2=CC=CN=C2N3CCC(C4=NN=CN4C)CC3

Storage & Solubility Information

Storage

Keep away from moisture,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (59.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9553 mL	14.7763 mL	29.5526 mL	147.7629 mL
5 mM	0.5911 mL	2.9553 mL	5.9105 mL	29.5526 mL
10 mM	0.2955 mL	1.4776 mL	2.9553 mL	14.7763 mL
20 mM	0.1478 mL	0.7388 mL	1.4776 mL	7.3881 mL
50 mM	0.0591 mL	0.2955 mL	0.5911 mL	2.9553 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: SEN177 chemical structure | SEN177 in vitro | SEN177 formula | SEN177 molecular weight