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IACS-9571 TFA

Name: IACS-9571 TFA
Brand: TargetMol
SKU: T88922
Rating: 4.5 (1 reviews)

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Catalog No. T88922Cas No. 1883598-69-3

Alias ASIS-P040 TFA

IACS-9571 (trifluoroacetate) serves as an inhibitor of the bromodomain proteins TRIM24 and BRPF1, exhibiting an IC50 of 8 nM and a Kd of 31 nM against TRIM24, and a Kd of 14 nM against BRPF1.

IACS-9571 TFA

😃Good

Catalog No. T88922Alias ASIS-P040 TFACas No. 1883598-69-3

IACS-9571 (trifluoroacetate) serves as an inhibitor of the bromodomain proteins TRIM24 and BRPF1, exhibiting an IC50 of 8 nM and a Kd of 31 nM against TRIM24, and a Kd of 14 nM against BRPF1.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,670	8-10 weeks	8-10 weeks
50 mg	$2,180	8-10 weeks	8-10 weeks
100 mg	$2,800	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	IACS-9571 (trifluoroacetate) serves as an inhibitor of the bromodomain proteins TRIM24 and BRPF1, exhibiting an IC50 of 8 nM and a Kd of 31 nM against TRIM24, and a Kd of 14 nM against BRPF1.
In vitro	IACS-9571 (trifluoroacetate) exhibits potent cellular activity with an EC50 value of 50 nM and demonstrates significant inhibitory effects on a spectrum of 32 bromodomains at a concentration of 1 μM. As a selective dual inhibitor of TRIM24/BRPF1, IACS-9571 (trifluoroacetate) achieves dissociation constants (Kd) of 1.3 nM and 2.1 nM, respectively, offering 9-fold and 21-fold selectivity over BRPF2 and BRPF3. Additionally, this compound does not affect the BET sub-family of bromodomains, showing exceptional selectivity greater than 7,700-fold when compared to BRD4 (1, 2) in relation to TRIM24.
Synonyms	ASIS-P040 TFA

Chemical Properties

Molecular Weight	756.79
Formula	C₃₄H₄₃F₃N₄O₁₀S
Cas No.	1883598-69-3
Smiles	O=C(O)C(F)(F)F.O=C1N(C2=CC(OC=3C=C(OCCC)C=C(OCCCCN(C)C)C3)=C(C=C2N1C)NS(=O)(=O)C4=CC=C(OC)C(OC)=C4)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc