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LY339434 HCl

Name: LY339434 HCl
Brand: TargetMol
SKU: T27947L
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27947L

Alias LY339434 HCl(219566-62-8 Free base)

LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA) receptors.

LY339434 HCl

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Purity: 97.19%

Catalog No. T27947LAlias LY339434 HCl(219566-62-8 Free base)

LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA) receptors.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	In Stock	In Stock
5 mg	$430	In Stock	In Stock
10 mg	$636	In Stock	In Stock
25 mg	$987	In Stock	In Stock
50 mg	$1,360	In Stock	In Stock
100 mg	$1,830	In Stock	In Stock
500 mg	$3,680	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:97.19%

ee:97.89%

Appearance:Solid

Color:Yellow

Resource Download

COA CSFC HNMR IC ORP LCMS

Product Introduction

Bioactivity

Description	LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA) receptors.
In vitro	LY339434 HCl (1-1000 μM) caused a concentration-dependent decrease in cell viability (EC(50)=11.4+/-1.2 μM). Labeling with nucleic acid binding dyes revealed that LY339434 HCl induced a few apoptotic-like characteristics. These findings indicate that in cultured murine cortical neurons, LY339434 HCl acts predominantly through N-methyl-D-aspartate (NMDA) receptors rather than GluR5 to affect neuronal death that is rapid and involves predominantly necrosis rather than morphological apoptosis.[1]
Synonyms	LY339434 HCl(219566-62-8 Free base)

Chemical Properties

Molecular Weight	349.81
Formula	C₁₈H₂₀ClNO₄
Smiles	OC([C@@H](N)C[C@H](C(O)=O)C/C=C/C1=CC2=C(C=CC=C2)C=C1)=O.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (142.93 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8587 mL	14.2935 mL	28.5869 mL	142.9347 mL
5 mM	0.5717 mL	2.8587 mL	5.7174 mL	28.5869 mL
10 mM	0.2859 mL	1.4293 mL	2.8587 mL	14.2935 mL
20 mM	0.1429 mL	0.7147 mL	1.4293 mL	7.1467 mL
50 mM	0.0572 mL	0.2859 mL	0.5717 mL	2.8587 mL
100 mM	0.0286 mL	0.1429 mL	0.2859 mL	1.4293 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc