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LY339434 HCl

Catalog No. T27947L

Synonyms: LY339434 HCl(219566-62-8 Free base)

LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA) receptors.

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LY339434 HCl, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 430.00
10 mg	In stock	$ 636.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,360.00
100 mg	In stock	$ 1,830.00
500 mg	In stock	$ 3,680.00

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Purity: 99.32%

ee: 98.54%

Purity: 97.41%

ee: 97.89%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA) receptors.

In vitro

LY339434 HCl (1-1000 μM) caused a concentration-dependent decrease in cell viability (EC(50)=11.4+/-1.2 μM). Labeling with nucleic acid binding dyes revealed that LY339434 HCl induced a few apoptotic-like characteristics. These findings indicate that in cultured murine cortical neurons, LY339434 HCl acts predominantly through N-methyl-D-aspartate (NMDA) receptors rather than GluR5 to affect neuronal death that is rapid and involves predominantly necrosis rather than morphological apoptosis.[1]

Synonyms	LY339434 HCl(219566-62-8 Free base)
Molecular Weight	349.81
Formula	C18H20ClNO4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Moldrich RX, et al. Excitotoxic profile of LY339434, a GluR5 agonist, in cultured murine cortical neurons. Brain Res. 2000 Apr 17;862(1-2):270-5. 2. Small B, et al. LY339434, a GluR5 kainate receptor agonist. Neuropharmacology. 1998 Oct-Nov;37(10-11):1261-7.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)- (S)-3,4-DCPG DL-AP3 DCB Caroverine hydrochloride Pomaglumetad methionil hydrochloride pep2-SVKI acetate KM02894

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Keywords

LY339434 HCl Neuroscience NMDAR GluR LY339434 HCl(219566-62-8 Free base) inhibitor inhibit

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