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GV-196771A

Name: GV-196771A
Brand: TargetMol
SKU: T11516
Price: 700 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11516Cas No. 166974-23-8

GV-196771A A novel NMDA receptor glycine site antagonist with potent antinociceptive activity.

GV-196771A

😃Good

Purity: 96.43%

Catalog No. T11516Cas No. 166974-23-8

GV-196771A A novel NMDA receptor glycine site antagonist with potent antinociceptive activity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$700	-	In Stock
5 mg	$1,800	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:96.43%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	GV-196771A A novel NMDA receptor glycine site antagonist with potent antinociceptive activity.
In vivo	GV196771A, developed for the treatment of neuropathic pain, is a potent antagonist of the modulatory glycine site of the N-methyl-D-aspartate receptor (NMDA receptor). It exhibits low oral bioavailability in rats and mice, with a bioavailability of less than 10% and a plasma clearance of approximately 2 mL/min/kg[1].

Chemical Properties

Molecular Weight	423.23
Formula	C₂₀H₁₃Cl₂N₂NaO₃
Cas No.	166974-23-8
Smiles	[O-]C(C1=C(C2=C(Cl)C=C(Cl)C=C2N1)/C=C3C(N(C4=CC=CC=C4)CC/3)=O)=O.[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc