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GNE-0723

Name: GNE-0723
Brand: TargetMol
SKU: T15407
Price: 457 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15407Cas No. 1883518-31-7

Alias GNE0723

GNE-0723 is a selective positive allosteric modulator of the NMDA receptor, with an EC50 of 21 nM for GluN2A. It can cross the blood-brain barrier (BBB) and improve outcomes in Dravet syndrome (DS) and Alzheimer's disease (AD).

GNE-0723

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Purity: 99.91%

Catalog No. T15407Alias GNE0723Cas No. 1883518-31-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$457	-	In Stock
5 mg	$1,060	-	In Stock
10 mg	$1,420	-	In Stock
25 mg	$2,120	-	In Stock
50 mg	$2,780	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

ee:98.22%

Appearance:Solid

Color:White

Resource Download

COA CNMR CSFC FNMR HNMR LCMS ORP

Product Introduction

Bioactivity

Description	GNE-0723 is a selective positive allosteric modulator of the NMDA receptor, with an EC50 of 21 nM for GluN2A. It can cross the blood-brain barrier (BBB) and improve outcomes in Dravet syndrome (DS) and Alzheimer's disease (AD).
Targets&IC50	GluN2D:6.2 μM（EC50）, GluN2C:7.4 μM（EC50）, GluN2A:21 nM （EC50）
In vitro	GNE-0723 is a brain-permeable NMDAR positive allosteric modulator with EC50 of 21 nM/7.4μM/6.2 μM for GluN2A/2C/2D. [1]
Synonyms	GNE0723

Chemical Properties

Molecular Weight	467.78
Formula	C₁₆H₈ClF₆N₅OS
Cas No.	1883518-31-7
Smiles	C(F)(F)(F)C1=C(N2C(S1)=NC(CN3N=C(C(F)(F)F)C=C3Cl)=CC2=O)[C@H]4[C@H](C#N)C4
Relative Density.	1.84 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (342.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1378 mL	10.6888 mL	21.3776 mL	106.8879 mL
5 mM	0.4276 mL	2.1378 mL	4.2755 mL	21.3776 mL
10 mM	0.2138 mL	1.0689 mL	2.1378 mL	10.6888 mL
20 mM	0.1069 mL	0.5344 mL	1.0689 mL	5.3444 mL
50 mM	0.0428 mL	0.2138 mL	0.4276 mL	2.1378 mL
100 mM	0.0214 mL	0.1069 mL	0.2138 mL	1.0689 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc