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GNE-0723

Name: GNE-0723
Brand: TargetMol
SKU: T15407
Price: 457 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15407Cas No. 1883518-31-7

Alias GNE0723

GNE-0723 is a selective positive allosteric modulator of the NMDA receptor, with an EC50 of 21 nM for GluN2A. It can cross the blood-brain barrier (BBB) and improve outcomes in Dravet syndrome (DS) and Alzheimer's disease (AD).

GNE-0723

🥰Excellent

Purity: 99.91%

Catalog No. T15407Alias GNE0723Cas No. 1883518-31-7

Pack Size	Price	Availability
1 mg	$457	In Stock
5 mg	$1,060	In Stock
10 mg	$1,420	In Stock
25 mg	$2,120	In Stock
50 mg	$2,780	In Stock

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Purity:99.91%

ee:98.22%

Resource Download

COA CNMR CSFC FNMR HNMR LCMS ORP

Product Introduction

Bioactivity

Description	GNE-0723 is a selective positive allosteric modulator of the NMDA receptor, with an EC50 of 21 nM for GluN2A. It can cross the blood-brain barrier (BBB) and improve outcomes in Dravet syndrome (DS) and Alzheimer's disease (AD).
Targets&IC50	GluN2C:7.4 μM（EC50）, GluN2D:6.2 μM（EC50）, GluN2A:21 nM （EC50）
In vitro	GNE-0723 is a brain-permeable NMDAR positive allosteric modulator with EC50 of 21 nM/7.4μM/6.2 μM for GluN2A/2C/2D. [1]
Synonyms	GNE0723

Chemical Properties

Molecular Weight	467.78
Formula	C₁₆H₈ClF₆N₅OS
Cas No.	1883518-31-7
Smiles	C(F)(F)(F)C1=C(N2C(S1)=NC(CN3N=C(C(F)(F)F)C=C3Cl)=CC2=O)[C@H]4[C@H](C#N)C4
Relative Density.	1.84 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (342.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1378 mL	10.6888 mL	21.3776 mL	106.8879 mL
5 mM	0.4276 mL	2.1378 mL	4.2755 mL	21.3776 mL
10 mM	0.2138 mL	1.0689 mL	2.1378 mL	10.6888 mL
20 mM	0.1069 mL	0.5344 mL	1.0689 mL	5.3444 mL
50 mM	0.0428 mL	0.2138 mL	0.4276 mL	2.1378 mL
100 mM	0.0214 mL	0.1069 mL	0.2138 mL	1.0689 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc