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10-Deacetylbaccatin III

Name: 10-Deacetylbaccatin III
Brand: TargetMol
SKU: T2197
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2197Cas No. 32981-86-5

10-Deacetylbaccatin-III is an intermediate for the preparation of taxol analogs, possessing anti-cancer activity.

10-Deacetylbaccatin III

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Purity: 99.21%

Catalog No. T2197Cas No. 32981-86-5

10-Deacetylbaccatin-III is an intermediate for the preparation of taxol analogs, possessing anti-cancer activity.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$31	In Stock	In Stock
500 mg	$64	In Stock	In Stock
1 g	$98	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.21%

Appearance:solid

Color:White

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COA HPLC HNMR LCMS

Product Introduction

10-Deacetylbaccatin III AI Summary

10-Deacetylbaccatin III demonstrates diverse biological activities across various assays and models. It shows high activity in affecting calcein accumulation in multidrug-resistant human 2780AD cells, with significant reductions at concentrations of 0.25 µg/ml (95.0%), 2.5 µg/ml (90.0%), and 25 µg/ml (93.0%) relative to the control. In human KB cells, it exhibits cytotoxic activity with an effective dose (ED50) of 1.0 µg/ml and an activity level of 16.0%. The compound also displays cytotoxicity against various human cell lines, including A498, NCI-H226, A549, PC-3, and H460 cells, with an IC50 of 3100 nM in H460 cells and moderate to low growth inhibition (1.6% to 27.0%) at 30 µg/ml after 48 hours. Additionally, it has antiproliferative activity against human cancer cell lines like MCF7, A549, A2780, and HCT8, with IC50 values ranging from 16000 nM to 25000 nM, and is less effective against mouse NIH/3T3 cells. 10-Deacetylbaccatin III also exhibits antiviral activity against SARS-CoV-2, inhibiting induced cytotoxicity in Caco-2 and VERO-6 cells, though the effectiveness was low. It shows antileishmanial activity in Leishmania donovani-infected BALB/c mice, reducing the parasitic load by 42.0% at a dose of 100 mg/kg. Additionally, it inhibits human HDAC6 enzyme activity in enzymatic assays, with inhibition percentages of -21.77% and -13.48% using commercial and custom peptide substrates, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

10-Deacetylbaccatin-III is an intermediate for the preparation of taxol analogs, possessing anti-cancer activity.

Chemical Properties

Molecular Weight	544.59
Formula	C₂₉H₃₆O₁₀
Cas No.	32981-86-5
Smiles	O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](O)C5)[H]
Relative Density.	1.2007 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 91.7 mg/mL (168.38 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8362 mL	9.1812 mL	18.3624 mL	91.8122 mL
5 mM	0.3672 mL	1.8362 mL	3.6725 mL	18.3624 mL
10 mM	0.1836 mL	0.9181 mL	1.8362 mL	9.1812 mL
20 mM	0.0918 mL	0.4591 mL	0.9181 mL	4.5906 mL
50 mM	0.0367 mL	0.1836 mL	0.3672 mL	1.8362 mL
100 mM	0.0184 mL	0.0918 mL	0.1836 mL	0.9181 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc