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Letolizumab
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Catalog No. T77061Cas No. 1450981-87-9
Alias BMS-986004, BMS986004, BMS2h-572-633-CT-L2
Letolizumab (BMS-986004) is a dimeric antibody targeting CD40L for the expression of mutant IgG1 that lacks effector functions including Fc binding and complement binding.1 Letolizumab does not induce platelet activation in vitro and does not affect coagulation factors or platelet counts/function after repeated dosing in non-human primates.
Letolizumab
Letolizumab
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Catalog No. T77061Alias BMS-986004, BMS986004, BMS2h-572-633-CT-L2Cas No. 1450981-87-9
Letolizumab (BMS-986004) is a dimeric antibody targeting CD40L for the expression of mutant IgG1 that lacks effector functions including Fc binding and complement binding.1 Letolizumab does not induce platelet activation in vitro and does not affect coagulation factors or platelet counts/function after repeated dosing in non-human primates.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $169 | In Stock | In Stock | |
| 5 mg | $448 | In Stock | In Stock | |
| 10 mg | $715 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,460 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.8% (SDS-PAGE); 99.2% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Letolizumab (BMS-986004) is a dimeric antibody targeting CD40L for the expression of mutant IgG1 that lacks effector functions including Fc binding and complement binding.1 Letolizumab does not induce platelet activation in vitro and does not affect coagulation factors or platelet counts/function after repeated dosing in non-human primates. |
| Targets&IC50 | CD40L trimer (human):3.6 nM, CD40L trimer (non-human primate):3.8 nM, CHO-CD40L (human):1.3 nM, CHO-CD40L (non-human primate):7.3 nM |
| In vitro | Letolizumab inhibited the viability of CD40L trimer and CHO-CD40L in human B-cells and in non-human primate B-cells with IC50 values of 3.6 nM and 1.3 nM, and 3.8 nM and 7.3 nM, respectively. [2] |
| In vivo | Letolizumab treatment at doses of 2, 10, and 20 mg/kg administered intravenously once a week for 10 weeks significantly prolonged the survival time of rhesus monkeys after kidney transplantation. [2] |
| Synonyms | BMS-986004, BMS986004, BMS2h-572-633-CT-L2 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TNFSF5/CD40L/CD154 |
| Molecular Weight | 38.99 kDa |
| Cas No. | 1450981-87-9 |
| Isotype | IgG1-AST-4xS |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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