Shopping Cart
Remove All
Your shopping cart is currently empty
Letolizumab (Synonyms: BMS-986004, BMS986004, BMS2h-572-633-CT-L2)
Catalog No. T77061 Copy Product Info
🥰Excellent
Letolizumab (BMS-986004) is a dimeric antibody targeting CD40L for the expression of mutant IgG1 that lacks effector functions including Fc binding and complement binding.1 Letolizumab does not induce platelet activation in vitro and does not affect coagulation factors or platelet counts/function after repeated dosing in non-human primates.
Letolizumab
Copy Product Info🥰Excellent
Catalog No. T77061
Synonyms BMS-986004, BMS986004, BMS2h-572-633-CT-L2
Letolizumab (BMS-986004) is a dimeric antibody targeting CD40L for the expression of mutant IgG1 that lacks effector functions including Fc binding and complement binding.1 Letolizumab does not induce platelet activation in vitro and does not affect coagulation factors or platelet counts/function after repeated dosing in non-human primates.
Letolizumab
Cas No. 1450981-87-9
Customer service consultation
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $169 | In Stock | In Stock | |
| 5 mg | $448 | In Stock | In Stock | |
| 10 mg | $715 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,460 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Cart
Add to Quotation
For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
Select Batch
Purity:98.8% (SDS-PAGE); 99.2% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Letolizumab (BMS-986004) is a dimeric antibody targeting CD40L for the expression of mutant IgG1 that lacks effector functions including Fc binding and complement binding.1 Letolizumab does not induce platelet activation in vitro and does not affect coagulation factors or platelet counts/function after repeated dosing in non-human primates. |
| Targets&IC50 | CHO-CD40L (human):1.3 nM, CHO-CD40L (non-human primate):7.3 nM, CD40L trimer (non-human primate):3.8 nM, CD40L trimer (human):3.6 nM |
| In vitro | Letolizumab inhibited the viability of CD40L trimer and CHO-CD40L in human B-cells and in non-human primate B-cells with IC50 values of 3.6 nM and 1.3 nM, and 3.8 nM and 7.3 nM, respectively. [2] |
| In vivo | Letolizumab treatment at doses of 2, 10, and 20 mg/kg administered intravenously once a week for 10 weeks significantly prolonged the survival time of rhesus monkeys after kidney transplantation. [2] |
| Synonyms | BMS-986004, BMS986004, BMS2h-572-633-CT-L2 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TNFSF5/CD40L/CD154 |
| Molecular Weight | 38.99 kDa |
| Cas No. | 1450981-87-9 |
| Isotype | IgG1-AST-4xS |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
Preview
Related Tags: buy Letolizumab | purchase Letolizumab | Letolizumab cost | order Letolizumab | Letolizumab in vivo | Letolizumab in vitro | Letolizumab molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.