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Kifunensine

Name: Kifunensine
Brand: TargetMol
SKU: T20628
Rating: 4.5 (1 reviews)

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Catalog No. T20628Cas No. 109944-15-2

Alias LY231514 disodium heptahydrate

Kifunensine, an alkaloid discovered in Kitasatosporia kifunense, functions as a glycosylation pathway inhibitor and immunomodulator. It strongly inhibits α-mannosidase I in the Golgi apparatus and may be utilised in studies of endoplasmic reticulum stress.

Kifunensine

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Catalog No. T20628Alias LY231514 disodium heptahydrateCas No. 109944-15-2

Pack Size	Price	Availability	Quantity
50 mg	$2,400	8-10 weeks

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Product Introduction

Bioactivity

Description	Kifunensine, an alkaloid discovered in Kitasatosporia kifunense, functions as a glycosylation pathway inhibitor and immunomodulator. It strongly inhibits α-mannosidase I in the Golgi apparatus and may be utilised in studies of endoplasmic reticulum stress.
In vitro	Methods: SK-N-SH cells were pretreated with kifunensine (1 μg/ml) for 72 hours to examine the effects of ERAD inhibition on UPR and ER stress. Results: Kifunensine decreased UPR activation and ER stress toxicity by inhibiting ERAD, and altered lysosomal morphology and distribution.[3]
In vivo	Methods: Kifunensine (250 μg, administered for 3 consecutive days) was intraperitoneally injected into C57BL/6 mice to investigate the role of MHCII glycosylation in carbohydrate antigen-specific immune responses of Parazacco spilurus subsp. spilurus. Results: Kifunensine treatment significantly reduced PSA-driven immune response, which could be restored by adoptive transfer of normally glycosylated APCs. [4]
Synonyms	LY231514 disodium heptahydrate

Chemical Properties

Molecular Weight	232.19
Formula	C₈H₁₂N₂O₆
Cas No.	109944-15-2
Smiles	[H][C@]12NC(=O)C(=O)N1[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O
Relative Density.	1.85 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (34.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3068 mL	21.5341 mL	43.0682 mL	215.3409 mL
5 mM	0.8614 mL	4.3068 mL	8.6136 mL	43.0682 mL
10 mM	0.4307 mL	2.1534 mL	4.3068 mL	21.5341 mL
20 mM	0.2153 mL	1.0767 mL	2.1534 mL	10.7670 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Kifunensine