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Kifunensine

Name: Kifunensine
Brand: TargetMol
SKU: T20628
Rating: 4.5 (1 reviews)

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Catalog No. T20628Cas No. 109944-15-2

Alias LY231514 disodium heptahydrate

Kifunensine, an alkaloid discovered in Kitasatosporia kifunense, functions as a glycosylation pathway inhibitor and immunomodulator. It strongly inhibits α-mannosidase I in the Golgi apparatus and may be utilised in studies of endoplasmic reticulum stress.

Kifunensine

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Catalog No. T20628Alias LY231514 disodium heptahydrateCas No. 109944-15-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$2,400	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Kifunensine, an alkaloid discovered in Kitasatosporia kifunense, functions as a glycosylation pathway inhibitor and immunomodulator. It strongly inhibits α-mannosidase I in the Golgi apparatus and may be utilised in studies of endoplasmic reticulum stress.
In vitro	Methods: SK-N-SH cells were pretreated with kifunensine (1 μg/ml) for 72 hours to examine the effects of ERAD inhibition on UPR and ER stress. Results: Kifunensine decreased UPR activation and ER stress toxicity by inhibiting ERAD, and altered lysosomal morphology and distribution.[3]
In vivo	Methods: Kifunensine (250 μg, administered for 3 consecutive days) was intraperitoneally injected into C57BL/6 mice to investigate the role of MHCII glycosylation in carbohydrate antigen-specific immune responses of Parazacco spilurus subsp. spilurus. Results: Kifunensine treatment significantly reduced PSA-driven immune response, which could be restored by adoptive transfer of normally glycosylated APCs. [4]
Synonyms	LY231514 disodium heptahydrate

Chemical Properties

Molecular Weight	232.19
Formula	C₈H₁₂N₂O₆
Cas No.	109944-15-2
Smiles	[H][C@]12NC(=O)C(=O)N1[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O
Relative Density.	1.85 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (34.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3068 mL	21.5341 mL	43.0682 mL	215.3409 mL
5 mM	0.8614 mL	4.3068 mL	8.6136 mL	43.0682 mL
10 mM	0.4307 mL	2.1534 mL	4.3068 mL	21.5341 mL
20 mM	0.2153 mL	1.0767 mL	2.1534 mL	10.7670 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc