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Kifunensine

Name: Kifunensine
Brand: TargetMol
SKU: T20628
Price: 2400 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20628Cas No. 109944-15-2

Alias LY231514 disodium heptahydrate

Kifunensine, an alkaloid discovered in Kitasatosporia kifunense, functions as a glycosylation pathway inhibitor and immunomodulator. It strongly inhibits α-mannosidase I in the Golgi apparatus and may be utilised in studies of endoplasmic reticulum stress.

Kifunensine

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Catalog No. T20628Alias LY231514 disodium heptahydrateCas No. 109944-15-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$2,400	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Kifunensine, an alkaloid discovered in Kitasatosporia kifunense, functions as a glycosylation pathway inhibitor and immunomodulator. It strongly inhibits α-mannosidase I in the Golgi apparatus and may be utilised in studies of endoplasmic reticulum stress.
In vitro	Methods: SK-N-SH cells were pretreated with kifunensine (1 μg/ml) for 72 hours to examine the effects of ERAD inhibition on UPR and ER stress. Results: Kifunensine decreased UPR activation and ER stress toxicity by inhibiting ERAD, and altered lysosomal morphology and distribution.[3]
In vivo	Methods: Kifunensine (250 μg, administered for 3 consecutive days) was intraperitoneally injected into C57BL/6 mice to investigate the role of MHCII glycosylation in carbohydrate antigen-specific immune responses of Parazacco spilurus subsp. spilurus. Results: Kifunensine treatment significantly reduced PSA-driven immune response, which could be restored by adoptive transfer of normally glycosylated APCs. [4]
Synonyms	LY231514 disodium heptahydrate

Chemical Properties

Molecular Weight	232.19
Formula	C₈H₁₂N₂O₆
Cas No.	109944-15-2
Smiles	[H][C@]12NC(=O)C(=O)N1[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O
Relative Density.	1.85 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (34.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 0.5 mg/mL (2.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3068 mL	21.5341 mL	43.0682 mL	215.3409 mL
5 mM	0.8614 mL	4.3068 mL	8.6136 mL	43.0682 mL
10 mM	0.4307 mL	2.1534 mL	4.3068 mL	21.5341 mL
20 mM	0.2153 mL	1.0767 mL	2.1534 mL	10.7670 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc