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Ipsalazide
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Catalog No. T19379Cas No. 82101-17-5
Ipsalazide is a novel salicylazosulfapyridine analog for the treatment of inflammatory bowel disease.
Ipsalazide
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Purity: 99.43%
Catalog No. T19379Cas No. 82101-17-5
Ipsalazide is a novel salicylazosulfapyridine analog for the treatment of inflammatory bowel disease.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $700 | - | In Stock | |
| 5 mg | $1,800 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.43%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ipsalazide is a novel salicylazosulfapyridine analog for the treatment of inflammatory bowel disease. |
| In vitro | Ipsalazide is designed with the replacement of the sulfapyridine of sulfasalazine by carrier molecules, aiming to mitigate side effects. Sulfasalazine exerts beneficial effects in colitis by releasing 5-aminosalicylic acid in the colon, but its use can be limited by side effects[1]. |
| In vivo | Within 7 days of a single oral dose of ipsalazide (4 g/kg in mice or 2 g/kg in rats), no deaths or visible abnormalities occurred. At postmortem, no abnormalities were observed. The carrier molecule of ipsalazide (ABG) is readily absorbed, with nearly half of the dose appearing in the urine. However, approximately 40% of the ABG was not recovered, and it is possible that this has undergone further metabolism, resulting in the loss of the aromatic amine function, which is the basis for the colorimetric measurement of ABG[1]. |
| Molecular Weight | 387.25 |
| Formula | C16H11N3Na2O6 |
| Cas No. | 82101-17-5 |
| Smiles | O=C(C1=CC(N=NC2=CC=C(C(NCC([O-])=O)=O)C=C2)=CC=C1O)[O-].[Na+].[Na+] |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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