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TUN-92046

Name: TUN-92046
Brand: TargetMol
SKU: T71961
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T71961Cas No. 13192-04-6

Alias T71961, DM-α-KG, Dimethyl 2-oxoglutarate, Dimethyl 2-ketoglutarate

TUN-92046 (Dimethyl 2-oxoglutarate) is a membrane-permeable alpha-ketoglutarate analogue that inhibits maladaptive autophagy in pressure overloading induced cardiomyopathy.

TUN-92046

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Purity: 98.58%

Catalog No. T71961Alias T71961, DM-α-KG, Dimethyl 2-oxoglutarate, Dimethyl 2-ketoglutarateCas No. 13192-04-6

TUN-92046 (Dimethyl 2-oxoglutarate) is a membrane-permeable alpha-ketoglutarate analogue that inhibits maladaptive autophagy in pressure overloading induced cardiomyopathy.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock

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Batch Information

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Purity:98.58%

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Product Introduction

Bioactivity

Description	TUN-92046 (Dimethyl 2-oxoglutarate) is a membrane-permeable alpha-ketoglutarate analogue that inhibits maladaptive autophagy in pressure overloading induced cardiomyopathy.
Synonyms	T71961, DM-α-KG, Dimethyl 2-oxoglutarate, Dimethyl 2-ketoglutarate

Chemical Properties

Molecular Weight	174.15
Formula	C₇H₁₀O₅
Cas No.	13192-04-6
Smiles	COC(=O)CCC(=O)C(=O)OC
Relative Density.	1.203 g/mL

Storage & Solubility Information

Storage

store under nitrogen,store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (287.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (14.36 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.7422 mL	28.7109 mL	57.4218 mL	287.1088 mL
5 mM	1.1484 mL	5.7422 mL	11.4844 mL	57.4218 mL
10 mM	0.5742 mL	2.8711 mL	5.7422 mL	28.7109 mL
20 mM	0.2871 mL	1.4355 mL	2.8711 mL	14.3554 mL
50 mM	0.1148 mL	0.5742 mL	1.1484 mL	5.7422 mL
100 mM	0.0574 mL	0.2871 mL	0.5742 mL	2.8711 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc