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PIT-1

Name: PIT-1
Brand: TargetMol
SKU: T23163
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23163Cas No. 53501-41-0

Alias PIT1

PIT-1 is a selective PIP3 antagonist that inhibits cancer cell survival and induces apoptosis by inhibiting PIP3-dependent PI3K/Akt signalling and the PH structural domain of Akt.

PIT-1

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Purity: 99.51%

Catalog No. T23163Alias PIT1Cas No. 53501-41-0

PIT-1 is a selective PIP3 antagonist that inhibits cancer cell survival and induces apoptosis by inhibiting PIP3-dependent PI3K/Akt signalling and the PH structural domain of Akt.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$31	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.51%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PIT-1 is a selective PIP3 antagonist that inhibits cancer cell survival and induces apoptosis by inhibiting PIP3-dependent PI3K/Akt signalling and the PH structural domain of Akt.
In vitro	In breast cancer cell lines such as MCF-7, PIT-1 (10–100 μM, 24–48 h) induces apoptosis, reduces cell viability, and significantly downregulates the expression of Pit-1 target genes, including GH, PRL, and GHRHR. Additionally, PIT-1 upregulates pro-apoptotic genes such as Bax and activates caspase-3, suggesting PIT-1 induces apoptosis through a mitochondrial pathway[1].
In vivo	In a breast cancer xenograft model using nude mice, PIT-1 (intraperitoneal injection) significantly inhibited tumor growth, reducing tumor volume by approximately 60% compared to the control group, with no apparent toxicity[1].
Synonyms	PIT1

Chemical Properties

Molecular Weight	351.77
Formula	C₁₄H₁₀ClN₃O₄S
Cas No.	53501-41-0
Smiles	O=C(NC(=S)NC1=CC(=CC(Cl)=C1O)N(=O)=O)C=2C=CC=CC2
Relative Density.	1.592 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (142.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8428 mL	14.2138 mL	28.4277 mL	142.1383 mL
5 mM	0.5686 mL	2.8428 mL	5.6855 mL	28.4277 mL
10 mM	0.2843 mL	1.4214 mL	2.8428 mL	14.2138 mL
20 mM	0.1421 mL	0.7107 mL	1.4214 mL	7.1069 mL
50 mM	0.0569 mL	0.2843 mL	0.5686 mL	2.8428 mL
100 mM	0.0284 mL	0.1421 mL	0.2843 mL	1.4214 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc