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JNJ-64619178

Name: JNJ-64619178
Brand: TargetMol
SKU: T15624
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15624Cas No. 2086772-26-9

JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.

JNJ-64619178

🥰Excellent

Purity: 99.63%

Catalog No. T15624Cas No. 2086772-26-9

JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.

Pack Size	Price	Availability
1 mg	$81	In Stock
5 mg	$179	In Stock
10 mg	$289	In Stock
25 mg	$597	In Stock
50 mg	$993	In Stock
100 mg	$1,746	In Stock
1 mL x 10 mM (in DMSO)	$192	In Stock

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Purity:99.63%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.
Targets&IC50	PRMT5:0.14 nM
In vitro	JNJ-64619178 displays effective and broad inhibition of cellular growth. JNJ-64619178 binds simultaneously to the S-adenosylmethionine (SAM)- and protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action [1].
In vivo	In several non-small cell lung cancer and small cell lung cancer mouse xenograft models, JNJ-64619178 (p.o.) causes efficient inhibition of dimethylation of SMD1/3 proteins, components of the splicing machinery and direct substrates of the methylosome [1].

Chemical Properties

Molecular Weight	483.36
Formula	C₂₂H₂₃BrN₆O₂
Cas No.	2086772-26-9
Smiles	Nc1nc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)ccc2cc1Br
Relative Density.	1.79 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (248.26 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0689 mL	10.3443 mL	20.6885 mL	103.4426 mL
5 mM	0.4138 mL	2.0689 mL	4.1377 mL	20.6885 mL
10 mM	0.2069 mL	1.0344 mL	2.0689 mL	10.3443 mL
20 mM	0.1034 mL	0.5172 mL	1.0344 mL	5.1721 mL
50 mM	0.0414 mL	0.2069 mL	0.4138 mL	2.0689 mL
100 mM	0.0207 mL	0.1034 mL	0.2069 mL	1.0344 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc