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Grosvenorine

Name: Grosvenorine
Brand: TargetMol
SKU: TN1714
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1714Cas No. 156980-60-8

Alias Grosvenorin

Grosvenorine (Grosvenorin) exhibits good antibacterial and antioxidant activities, with its metabolites possessing more potent activities, intestinal bacteria play an important role in the gastrointestinal metabolism of grosvenorine and significantly affect its pharmacological activities.

Grosvenorine

🥰Excellent

Purity: 99.6%

Catalog No. TN1714Alias GrosvenorinCas No. 156980-60-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	In Stock	In Stock
5 mg	$213	In Stock	In Stock
10 mg	$328	In Stock	In Stock
25 mg	$552	In Stock	In Stock
50 mg	$787	In Stock	In Stock
100 mg	$1,070	-	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.6%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Grosvenorine (Grosvenorin) exhibits good antibacterial and antioxidant activities, with its metabolites possessing more potent activities, intestinal bacteria play an important role in the gastrointestinal metabolism of grosvenorine and significantly affect its pharmacological activities.
In vitro	The Grosvenorine metabolism in an in vitro simulated human gastrointestinal tract (including artificial gastric juice, artificial intestinal juice and intestinal flora), as well as its pharmacological activities (including anti-complement, antibacterial and antioxidant activities), was investigated. The results showed that Grosvenorine was metabolized by human intestinal flora; its four metabolites were isolated by semi-preparative HPLC and identified by NMR as kaempferitrin, afzelin, α±-rhamnoisorobin, and kaempferol. Further pharmacological evaluation showed that Grosvenorine exhibited good antibacterial and antioxidant activities, with its metabolites possessing more potent activities. Although Grosvenorine did not present obvious anticomplement activity, its metabolites showed interesting activities.
Synonyms	Grosvenorin

Chemical Properties

Molecular Weight	740.66
Formula	C₃₃H₄₀O₁₉
Cas No.	156980-60-8
Smiles	[H][C@@]1(O[C@H]2[C@H](Oc3cc(O)c4c(c3)oc(-c3ccc(O)cc3)c(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)c4=O)O[C@@H](C)[C@H](O)[C@H]2O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.	1.74 g/cm3 at 20℃
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (67.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3501 mL	6.7507 mL	13.5015 mL	67.5074 mL
5 mM	0.2700 mL	1.3501 mL	2.7003 mL	13.5015 mL
10 mM	0.1350 mL	0.6751 mL	1.3501 mL	6.7507 mL
20 mM	0.0675 mL	0.3375 mL	0.6751 mL	3.3754 mL
50 mM	0.0270 mL	0.1350 mL	0.2700 mL	1.3501 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc