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PSI-697

Name: PSI-697
Brand: TargetMol
SKU: T16676
Price: 137 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16676Cas No. 851546-61-7

Alias WAY-197697, WAY197697, PSI697, P-Selectin Inhibitor

PSI-697 (P-Selectin Inhibitor) is an orally active P-selectin inhibitor with anti-inflammatory and anti-thrombotic effects, useful for studying cardiovascular diseases such as atherosclerosis.

PSI-697

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Purity: 98.97%

Catalog No. T16676Alias WAY-197697, WAY197697, PSI697, P-Selectin InhibitorCas No. 851546-61-7

PSI-697 (P-Selectin Inhibitor) is an orally active P-selectin inhibitor with anti-inflammatory and anti-thrombotic effects, useful for studying cardiovascular diseases such as atherosclerosis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$137	-	In Stock
5 mg	$347	-	In Stock
10 mg	$496	-	In Stock
25 mg	$962	-	In Stock
1 mL x 10 mM (in DMSO)	$278	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.97%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	PSI-697 (P-Selectin Inhibitor) is an orally active P-selectin inhibitor with anti-inflammatory and anti-thrombotic effects, useful for studying cardiovascular diseases such as atherosclerosis.
Targets&IC50	P-selectin:50-125 μM
In vitro	PSI-697 inhibits the binding of soluble human P-selectin to PSGL-1 in a concentration-dependent manner with IC50=50-125 μM. [1]
In vivo	In a rat model of surgical inflammation, PSI-697 (50 mg/kg, orally) significantly reduced rolling white blood cell count by 39% In a rat venous thrombosis model, PS-697 (100 mg/kg, orally) reduced thrombus weight by 18% relative to the carrier (P < 0.05) without prolonged bleeding time. In a rat model of carotid artery injury, PSI-697 (30 or 15 mg/kg oral) administered 1 hour before arterial injury and once daily thereafter for 13 days resulted in a dose-dependent reduction of 40.2% in the intima/media ratio. [1] In a venous thrombosis rat stenosis model, PSI-697 (30 mg/kg; The thickening of the intima of the venous wall was significantly reduced by daily oral force-feeding. [2]
Synonyms	WAY-197697, WAY197697, PSI697, P-Selectin Inhibitor

Chemical Properties

Molecular Weight	367.83
Formula	C₂₁H₁₈ClNO₃
Cas No.	851546-61-7
Smiles	O=C(O)C1=C(O)C(=NC2=C1C=CC3=C2CCCC3)CC4=CC=C(Cl)C=C4
Relative Density.	1.383 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (108.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7186 mL	13.5932 mL	27.1865 mL	135.9324 mL
5 mM	0.5437 mL	2.7186 mL	5.4373 mL	27.1865 mL
10 mM	0.2719 mL	1.3593 mL	2.7186 mL	13.5932 mL
20 mM	0.1359 mL	0.6797 mL	1.3593 mL	6.7966 mL
50 mM	0.0544 mL	0.2719 mL	0.5437 mL	2.7186 mL
100 mM	0.0272 mL	0.1359 mL	0.2719 mL	1.3593 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc