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TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

(Z)-Guggulsterone

🥰Excellent
Catalog No. T17280Cas No. 39025-23-5

(Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.

(Z)-Guggulsterone
Other Forms of (Z)-Guggulsterone:

(Z)-Guggulsterone

🥰Excellent
Purity: 99.72%
Catalog No. T17280Cas No. 39025-23-5
(Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.
Pack SizePriceAvailabilityQuantity
5 mg$91In Stock
10 mg$131In Stock
25 mg$261In Stock
50 mg$391In Stock
100 mg$587In Stock
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Purity:99.72%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
(Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.
In vitro
In HUVEC, Z-guggulsterone (10, 20 μM; 24 or 48 hours) induces a reduction in the level of VEGF-R2 protein [1].
In vivo
In tumor volume and wet tumor weight, Z-guggulsterone (p.o.; 1 mg; 5 times/week) causes a statistically significant reduction [1].
Chemical Properties
Molecular Weight312.45
FormulaC21H28O2
Cas No.39025-23-5
SmilesC\C=C1/C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Relative Density.1.10 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: < 1 mg/mL (insoluble or slightly soluble)

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Keywords

VEGF-R2VEGFRVascular endothelial growth factor receptorProtein kinase BPKBInhibitorinhibitGuggulsteroneApoptosisAkt(Z)-Guggulsterone(Z)Guggulsterone(Z) Guggulsterone
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