Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HPK1-IN-22 (compound ZYF0033) is a haematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of less than 10 nM for MBP protein-based phosphorylation inhibition. HPK1-IN-22 reduces phosphorylation of SLP76 (serine 376) and promotes anti-cancer immune responses. HPK1-IN-22 inhibits tumor growth and increases intra-tumor infiltration of DCs, NK cells and CD107a+CD8+ T cells, but decreases infiltration of T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells and LAG3+CD8+ T cells in a 4T-1 homozygous mouse model.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 142.00 | |
5 mg | 5 days | $ 266.00 | |
25 mg | 8-10 weeks | $ 1,240.00 | |
50 mg | 8-10 weeks | $ 1,620.00 | |
100 mg | 8-10 weeks | $ 2,500.00 |
Description | HPK1-IN-22 (compound ZYF0033) is a haematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of less than 10 nM for MBP protein-based phosphorylation inhibition. HPK1-IN-22 reduces phosphorylation of SLP76 (serine 376) and promotes anti-cancer immune responses. HPK1-IN-22 inhibits tumor growth and increases intra-tumor infiltration of DCs, NK cells and CD107a+CD8+ T cells, but decreases infiltration of T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells and LAG3+CD8+ T cells in a 4T-1 homozygous mouse model. |
Molecular Weight | 462.61 |
Formula | C26H30N4O2S |
CAS No. | 2380300-79-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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HPK1-IN-22 2380300-79-6 inhibitor inhibit