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ZYF0033

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Catalog No. T62927Cas No. 2380300-79-6
Alias ZYF 0033, HPK1-IN-22

ZYF0033 is an orally effective small molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1) that inhibits the phosphorylation of MBP proteins.HPK1-IN-22 promotes anticancer immune responses by decreasing the phosphorylation of SLP76 (serine 76), and has the potential to inhibit tumor growth and mediate immune responses.

ZYF0033

ZYF0033

😃Good
Purity: 99.70%
Catalog No. T62927Alias ZYF 0033, HPK1-IN-22Cas No. 2380300-79-6
ZYF0033 is an orally effective small molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1) that inhibits the phosphorylation of MBP proteins.HPK1-IN-22 promotes anticancer immune responses by decreasing the phosphorylation of SLP76 (serine 76), and has the potential to inhibit tumor growth and mediate immune responses.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$142In StockIn Stock
5 mg$266In StockIn Stock
10 mg$453-In Stock
25 mg$955-In Stock
50 mg$1,620-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.70%
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Product Introduction

Bioactivity
Description
ZYF0033 is an orally effective small molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1) that inhibits the phosphorylation of MBP proteins.HPK1-IN-22 promotes anticancer immune responses by decreasing the phosphorylation of SLP76 (serine 76), and has the potential to inhibit tumor growth and mediate immune responses.
In vitro
ZYF0033 (HPK1-IN-22) (100 nM, 24 h) reduces the phosphorylation of SLP76 (serine 376) in T cells, leading to HPK1 inhibition and increasing the proliferation of CD4+ and CD8+ T cells and the secretion of IFN-γ. [1]
SynonymsZYF 0033, HPK1-IN-22
Chemical Properties
Molecular Weight462.61
FormulaC26H30N4O2S
Cas No.2380300-79-6
SmilesOC(C#CC1=CC=CC(=C1)COC=2C=C(C=NC2N)C=3SC(=NC3)C4CCN(C)CC4)(C)C
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (172.93 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.13 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1616 mL10.8082 mL21.6165 mL108.0824 mL
5 mM0.4323 mL2.1616 mL4.3233 mL21.6165 mL
10 mM0.2162 mL1.0808 mL2.1616 mL10.8082 mL
20 mM0.1081 mL0.5404 mL1.0808 mL5.4041 mL
50 mM0.0432 mL0.2162 mL0.4323 mL2.1616 mL
100 mM0.0216 mL0.1081 mL0.2162 mL1.0808 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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