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SHS4121705

Name: SHS4121705
Brand: TargetMol
SKU: T35636
Rating: 4.5 (1 reviews)

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Catalog No. T35636Cas No. 2379550-82-8

SHS4121705 is an orally bioavailable mitochondrial uncoupler.1It increases oxygen consumption rate in L6 rat myoblast cells with an EC50value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH).

SHS4121705

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Catalog No. T35636Cas No. 2379550-82-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$423	35 days	35 days
5 mg	$667	35 days	35 days
10 mg	$1,180	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	313.19
Formula	C₁₁H₆F₃N₅O₃
Cas No.	2379550-82-8
Smiles	N(C1=NC=2C(=NC1=O)NON2)C3=CC=C(OC(F)(F)F)C=C3
Relative Density.	1.81 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 30 mg/mL (95.79 mM), Sonication is recommended.

DMSO: 25 mg/mL (79.82 mM), Sonication is recommended.

DMF: 10 mg/mL (31.93 mM), Sonication is recommended.

Solution Preparation Table

DMF/DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.1929 mL	15.9647 mL	31.9295 mL	159.6475 mL
5 mM	0.6386 mL	3.1929 mL	6.3859 mL	31.9295 mL
10 mM	0.3193 mL	1.5965 mL	3.1929 mL	15.9647 mL
20 mM	0.1596 mL	0.7982 mL	1.5965 mL	7.9824 mL

DMSO/Ethanol

	1mg	5mg	10mg	50mg
50 mM	0.0639 mL	0.3193 mL	0.6386 mL	3.1929 mL

Calculator

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Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc