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Panduratin A
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Catalog No. T33875Cas No. 89837-52-5
Panduratin A is a natural chalcone derivative with inhibitory activity against MMP-9 in human oral epidermoid carcinoma KB cells; inhibitory activity against the NS3 protease of DENV-2 (Ki=25 μM); significant cytotoxicity against human androgen-independent prostate cancer cells PC-3 and DU-145; and also able to activate the LKB1-AMPK- PPARα /δ signaling pathway and enhance the oxidative capacity of myocyte mitochondria.
Panduratin A
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Purity: 99.58%
Catalog No. T33875Cas No. 89837-52-5
Panduratin A is a natural chalcone derivative with inhibitory activity against MMP-9 in human oral epidermoid carcinoma KB cells; inhibitory activity against the NS3 protease of DENV-2 (Ki=25 μM); significant cytotoxicity against human androgen-independent prostate cancer cells PC-3 and DU-145; and also able to activate the LKB1-AMPK- PPARα /δ signaling pathway and enhance the oxidative capacity of myocyte mitochondria.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $183 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.58%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
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| Description | Panduratin A is a natural chalcone derivative with inhibitory activity against MMP-9 in human oral epidermoid carcinoma KB cells; inhibitory activity against the NS3 protease of DENV-2 (Ki=25 μM); significant cytotoxicity against human androgen-independent prostate cancer cells PC-3 and DU-145; and also able to activate the LKB1-AMPK- PPARα /δ signaling pathway and enhance the oxidative capacity of myocyte mitochondria. |
| Targets&IC50 | Calu-1 cells:3.98 μM, H1299 cells:4.73 μM, A549 cells:6.26 μM |
| In vitro | Panduratin A exhibited potent antiproliferative effects in multiple human lung cancer cell lines (A549, H1299, Calu-1), with IC₅₀ values after 72 hours of treatment being 6.26, 4.73, and 3.98 μM, respectively. In A549 cells, Panduratin A (2.5–10 μM) induced dose-dependent apoptosis, G0/G1 arrest, mitochondrial membrane depolarization, and increased ROS levels within 48 hours. Panduratin A also suppressed activation of PI3K/AKT and MAPK pathways[1]. |
| In vivo | In A549 xenograft-bearing mice, oral administration of Panduratin A at 25 mg/kg once daily for 14 days significantly suppressed tumor growth by approximately 55% without affecting body weight or causing observable toxicity. Tumor tissues showed increased Bax, decreased Bcl-2, and enhanced cleaved caspase-3 expression, confirming its pro-apoptotic mechanism[1]. |
| Molecular Weight | 406.51 |
| Formula | C26H30O4 |
| Cas No. | 89837-52-5 |
| Smiles | C(=O)([C@H]1[C@@H](CC=C(C)[C@H]1CC=C(C)C)C2=CC=CC=C2)C3=C(O)C=C(OC)C=C3O |
| Relative Density. | 1.128 g/cm3 |
| Storage | store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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