IL-5R alpha/CD125 Protein, Human, Recombinant (hFc)

Name: IL-5R alpha/CD125 Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPJ-00266
Rating: 4.5 (1 reviews)

(Synonyms: Interleukin-5 receptor subunit α, Interleukin-5 receptor subunit alpha, IL-5R-α, IL-5R-alpha, IL-5RA, IL5RA, IL-5R subunit α, IL-5R subunit alpha, IL5R, IL-5 receptor subunit α, IL-5 receptor subunit alpha, CDw125, CD125) Copy Product Info

Synonyms: Interleukin-5 receptor subunit α, Interleukin-5 receptor subunit alpha, IL-5R-α, IL-5R-alpha, IL-5RA, IL5RA, IL-5R subunit α, IL-5R subunit alpha, IL5R, IL-5 receptor subunit α, IL-5 receptor subunit alpha, CDw125, CD125

Catalog No. TMPJ-00266 Copy Product Info

IL-5R alpha/CD125 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 70-85 KDa and the accession number is Q01344.

Pack Size	Price	USA Stock	Global Stock
5 µg	$112	35 days	35 days
10 µg	$183	35 days	35 days
20 µg	$292	35 days	35 days
50 µg	$545	35 days	35 days
100 µg	$792	35 days	35 days
200 µg	$1,150	35 days	35 days
500 µg	$1,900	35 days	35 days
1 mg	$2,970	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	IL-5R alpha/CD125 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 70-85 KDa and the accession number is Q01344.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q01344
Amino Acid	Asp21-Glu335
Construction	Asp21-Glu335
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	Interleukin-5 receptor subunit α, Interleukin-5 receptor subunit alpha, IL-5R-α, IL-5R-alpha, IL-5RA, IL5RA, IL-5R subunit α, IL-5R subunit alpha, IL5R, IL-5 receptor subunit α, IL-5 receptor subunit alpha, CDw125, CD125
Research Background	Interleukin-5 Receptor alpha (IL-5Rα, CD125) is a 60 kDa hematopoietin receptor that plays a dominant role in eosinophil biology. Mature human IL-5 Rα consists of a 322 aa extracellular domain (ECD) with a WSxWS motif and a four cysteine motif, a 20 aa transmembrane segment, and a 58 aa cytoplasmic domain. Within the ECD, human IL-5Rα shares 71% aa sequence identity with mouse and rat IL-5 Rα. Alternate splicing of human IL-5 Rα generates soluble secreted forms which function as IL-5 antagonists. The high affinity receptor for IL-5 is a complex that consists of the ligand binding IL-5 Rα and the transmembrane common β chain (βc/CD131) which is shared with the receptor complexes for IL-3 and GMCSF. IL-5 Rα binds IL-5 at low affinity and then associates with preformed βc oligomers to form the signaling competent receptor complex. IL-5 stimulation of CD34+ hematopoietic progenitor cells induces the up-regulation of transmembrane IL-5Rα followed by eosinophilic differentiation and activation.

Chemical Properties

Molecular Weight

70-85 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

CD-125CD 125

Related Tags: IL-5R alpha/CD125 Protein, Human, Recombinant (hFc) chemical structure | IL-5R alpha/CD125 Protein, Human, Recombinant (hFc) molecular weight