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Anti-STK3 Antibody (7H202)
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Catalog No. TMAH-01144
Alias STK 3, STE20-like kinase MST2, Serine/threonine-protein kinase Krs-1, Serine/threonine-protein kinase 3, MST-2, MST2, Mammalian STE20-like protein kinase 2, KRS1, EC 2.7.11.1
Anti-STK3 Antibody (7H202) is an antibody targeting STK3. Anti-STK3 Antibody (7H202) can be used in ELISA, WB.
Anti-STK3 Antibody (7H202)
Anti-STK3 Antibody (7H202)
😃Good
Catalog No. TMAH-01144Alias STK 3, STE20-like kinase MST2, Serine/threonine-protein kinase Krs-1, Serine/threonine-protein kinase 3, MST-2, MST2, Mammalian STE20-like protein kinase 2, KRS1, EC 2.7.11.1
Anti-STK3 Antibody (7H202) is an antibody targeting STK3. Anti-STK3 Antibody (7H202) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-STK3 Antibody (7H202) is an antibody targeting STK3. Anti-STK3 Antibody (7H202) can be used in ELISA, WB. |
| Alias | STK 3, STE20-like kinase MST2, Serine/threonine-protein kinase Krs-1, Serine/threonine-protein kinase 3, MST-2, MST2, Mammalian STE20-like protein kinase 2, KRS1, EC 2.7.11.1 |
| Ig Type | Rabbit IgG |
| Clone | 7H202 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in: U251 whole cell lysate, U87 whole cell lysate, MCF-7 whole cell lysate, Hela whole cell lysate -All lanes: STK3 antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 57, 60 kDa -Observed band size: 50-70 kDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:2000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Nucleus. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1. Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human STK3 |
| Antigen Species | Human |
| Gene ID | 6788 |
| Uniprot ID | |
| Biology Area | Cell biology, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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