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PSB-1901

Name: PSB-1901
Brand: TargetMol
SKU: T69675
Price: 373 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T69675Cas No. 2332835-02-4

Alias PSB-1901 free base, PSB1901, PSB 1901

PSB-1901 is a highly potent and selective A2B adenosine receptor antagonist exhibiting picomolar affinity for human A2BAR with exceptional subtype selectivity exceeding 10,000-fold over other adenosine receptors, while maintaining comparable potency in mouse A2BAR, making PSB-1901 a powerful pharmacological probe for preclinical investigations of adenosine-mediated signaling pathways.

PSB-1901

😃Good

Purity: 99.65%

Catalog No. T69675Alias PSB-1901 free base, PSB1901, PSB 1901Cas No. 2332835-02-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$373	-	In Stock
5 mg	$893	-	In Stock
10 mg	$1,220	-	In Stock
25 mg	$1,820	-	In Stock
50 mg	$2,380	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.65%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PSB-1901 is a highly potent and selective A2B adenosine receptor antagonist exhibiting picomolar affinity for human A2BAR with exceptional subtype selectivity exceeding 10,000-fold over other adenosine receptors, while maintaining comparable potency in mouse A2BAR, making PSB-1901 a powerful pharmacological probe for preclinical investigations of adenosine-mediated signaling pathways.
Targets&IC50	P2Y6 Receptor:< 100 nM (EC50)
In vitro	In pharmacological assays, PSB-1901 acted as a full agonist of the human P2Y6 receptor with an EC50 in the nM range, triggering Gq-protein coupled signaling and intracellular calcium mobilization [1].
In vivo	In physiological models, PSB-1901 is used to investigate P2Y6-mediated biological responses. In the immune system, activation of P2Y6 receptors on microglia drives phagocytosis, a process for clearing cellular debris and pathogens. In the cardiovascular system, PSB-1901 is associated with vasoconstriction. Its metabolic stability allows for the study of prolonged physiological effects without confounding factors from rapid ligand degradation [1].
Synonyms	PSB-1901 free base, PSB1901, PSB 1901

Chemical Properties

Molecular Weight	573.46
Formula	C₂₄H₂₅BrN₆O₄S
Cas No.	2332835-02-4
Smiles	O=C1NC=2N=C(NC2C(=O)N1CCC)C=3C=CC(=CC3)S(=O)(=O)N4CCN(C5=CC=C(Br)C=C5)CC4

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (139.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7438 mL	8.7190 mL	17.4380 mL	87.1900 mL
5 mM	0.3488 mL	1.7438 mL	3.4876 mL	17.4380 mL
10 mM	0.1744 mL	0.8719 mL	1.7438 mL	8.7190 mL
20 mM	0.0872 mL	0.4360 mL	0.8719 mL	4.3595 mL
50 mM	0.0349 mL	0.1744 mL	0.3488 mL	1.7438 mL
100 mM	0.0174 mL	0.0872 mL	0.1744 mL	0.8719 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc