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PSB-1901

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Catalog No. T69675Cas No. 2332835-02-4
Alias PSB-1901 free base, PSB1901, PSB 1901

PSB-1901 is a highly potent and selective A2B adenosine receptor antagonist exhibiting picomolar affinity for human A2BAR with exceptional subtype selectivity exceeding 10,000-fold over other adenosine receptors, while maintaining comparable potency in mouse A2BAR, making PSB-1901 a powerful pharmacological probe for preclinical investigations of adenosine-mediated signaling pathways.

PSB-1901

PSB-1901

😃Good
Purity: 99.65%
Catalog No. T69675Alias PSB-1901 free base, PSB1901, PSB 1901Cas No. 2332835-02-4
PSB-1901 is a highly potent and selective A2B adenosine receptor antagonist exhibiting picomolar affinity for human A2BAR with exceptional subtype selectivity exceeding 10,000-fold over other adenosine receptors, while maintaining comparable potency in mouse A2BAR, making PSB-1901 a powerful pharmacological probe for preclinical investigations of adenosine-mediated signaling pathways.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$373-In Stock
5 mg$893-In Stock
10 mg$1,220-In Stock
25 mg$1,820-In Stock
50 mg$2,380-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.65%
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Product Introduction

Bioactivity
Description
PSB-1901 is a highly potent and selective A2B adenosine receptor antagonist exhibiting picomolar affinity for human A2BAR with exceptional subtype selectivity exceeding 10,000-fold over other adenosine receptors, while maintaining comparable potency in mouse A2BAR, making PSB-1901 a powerful pharmacological probe for preclinical investigations of adenosine-mediated signaling pathways.
Targets&IC50
P2Y6 Receptor:< 100 nM (EC50)
SynonymsPSB-1901 free base, PSB1901, PSB 1901
Chemical Properties
Molecular Weight573.46
FormulaC24H25BrN6O4S
Cas No.2332835-02-4
SmilesO=C1NC=2N=C(NC2C(=O)N1CCC)C=3C=CC(=CC3)S(=O)(=O)N4CCN(C5=CC=C(Br)C=C5)CC4
ColorWhite
AppearanceSolid
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (139.5 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7438 mL8.7190 mL17.4380 mL87.1900 mL
5 mM0.3488 mL1.7438 mL3.4876 mL17.4380 mL
10 mM0.1744 mL0.8719 mL1.7438 mL8.7190 mL
20 mM0.0872 mL0.4360 mL0.8719 mL4.3595 mL
50 mM0.0349 mL0.1744 mL0.3488 mL1.7438 mL
100 mM0.0174 mL0.0872 mL0.1744 mL0.8719 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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