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Anti-Coagulation factor XI/F11 Antibody (5C508)
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Catalog No. TMAY-00583
Alias FXI, coagulation factor XI, coagulation factor 11
Anti-Coagulation factor XI/F11 Antibody (5C508) is a Mouse antibody targeting Coagulation factor XI/F11. Anti-Coagulation factor XI/F11 Antibody (5C508) can be used in ELISA.
Anti-Coagulation factor XI/F11 Antibody (5C508)
Anti-Coagulation factor XI/F11 Antibody (5C508)
😃Good
Catalog No. TMAY-00583Alias FXI, coagulation factor XI, coagulation factor 11
Anti-Coagulation factor XI/F11 Antibody (5C508) is a Mouse antibody targeting Coagulation factor XI/F11. Anti-Coagulation factor XI/F11 Antibody (5C508) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Coagulation factor XI/F11 Antibody (5C508) is a Mouse antibody targeting Coagulation factor XI/F11. Anti-Coagulation factor XI/F11 Antibody (5C508) can be used in ELISA. |
| Alias | FXI, coagulation factor XI, coagulation factor 11 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 5C508 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Factor XI (rh Factor XI; TMPY-01104; NP_000119.1; Met 1-Val 625). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa and then is processed into a disulfide-bond linked homodimer. FXI is a homodimer, with each subunit containing four apple domains and a protease domain. The apple domains form a disk structure with binding sites for platelets, high molecular weight kininogen, and the substrate factor IX (FIX). FXI is converted to the active protease FXIa by cleavage of the Arg369-Ile370 bond on each subunit. After the activation reaction, Factor XIa is composed of two heavy and two light chains held together by three disulfide bonds. The heavy chains are derived from the amino termini of the zymogen and responsible for the binding of factor XI to high molecular weight kininogen and for the activation of factor IX, while the light chain contains the catalytic portion of the enzyme and is homologous to the trypsin family of serine proteases. FXI deficiency is a disorder characterized by a mild or no bleeding tendency. Severe FXI deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human FXI protein (TMPY-01104) |
| Antigen Species | Human |
| Biology Area | Serine Proteases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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