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Anti-DNA Polymerase delta, catalytic subunit Polyclonal Antibody

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Catalog No. TMAB-05216

Anti-DNA Polymerase delta, catalytic subunit Polyclonal Antibody is a Rabbit antibody targeting DNA Polymerase delta, catalytic subunit. Anti-DNA Polymerase delta, catalytic subunit Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-DNA Polymerase delta, catalytic subunit Polyclonal Antibody

Anti-DNA Polymerase delta, catalytic subunit Polyclonal Antibody

😃Good
Catalog No. TMAB-05216
Anti-DNA Polymerase delta, catalytic subunit Polyclonal Antibody is a Rabbit antibody targeting DNA Polymerase delta, catalytic subunit. Anti-DNA Polymerase delta, catalytic subunit Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2227-10 days7-10 days
100 μL$3717-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-DNA Polymerase delta, catalytic subunit Polyclonal Antibody is a Rabbit antibody targeting DNA Polymerase delta, catalytic subunit. Anti-DNA Polymerase delta, catalytic subunit Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Mouse (predicted:Human,Rat,Dog,Pig,Cow,Sheep)
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundDNA replication, recombination and repair, all of which are necessary for genome stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). Exonucleases involved in these processes include DNA polymerases, including DNA pol ∂ and é. DNA pol ∂ consists of two subunits, p125 which interacts directly with the sliding DNA clamp protein PCNA, and p50 (3,4). DNA pol ∂ can be regulated by cell cycle proteins (5). DNA pol é is a multiple subunit enzyme, the catalytic subunit of which is encoded by the POL2 gene (6,7). The exact reactions catalyzed by DNA pol ∂ and é on leading and lagging strands have not yet been elucidated.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human DNA Polymerase delta, catalytic subunit
Antigen Species
Human
Gene Name
POLD1
Gene ID
Protein Name
DNA polymerase delta catalytic subunit
Uniprot ID
Function
Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.
Chemical Properties
Molecular WeightTheoretical: 124 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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