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Anti-Bcl-2 Antibody (9K951)
😃Good
Catalog No. TMAB-03059
Anti-Bcl-2 Antibody (9K951) is a Rabbit antibody targeting Bcl-2. Anti-Bcl-2 Antibody (9K951) can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB.
Anti-Bcl-2 Antibody (9K951)
Anti-Bcl-2 Antibody (9K951)
😃Good
Catalog No. TMAB-03059
Anti-Bcl-2 Antibody (9K951) is a Rabbit antibody targeting Bcl-2. Anti-Bcl-2 Antibody (9K951) can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Bcl-2 Antibody (9K951) is a Rabbit antibody targeting Bcl-2. Anti-Bcl-2 Antibody (9K951) can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB. |
| Ig Type | IgG |
| Clone | 9K951 |
| Reactivity | Human |
| Application | |
| Recommended Dose | FCM=1 μg/Test; ICC/IF=1:50-200; IF=1:200-500; IHC-Fr=1:200-500; IHC-P=1:200-500; WB=1:1000-5000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. |
| Tissue Specificity | Expressed in a variety of tissues. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Research Background | The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8). |
| Immunogen | Recombinant Protein: human Bcl-2 protein |
| Antigen Species | Human |
| Gene Name | BCL2 |
| Gene ID | |
| Protein Name | Apoptosis regulator Bcl-2 |
| Uniprot ID | |
| Function | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). |
| Molecular Weight | Theoretical: 26 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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