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LUF7244
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Catalog No. T61421Cas No. 1821638-43-0
LUF7244, a selective allosteric modulator of K v 11.1 channels, effectively suppresses early afterdepolarizations and holds potential for anti-arrhythmia research [1].
LUF7244
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Catalog No. T61421Cas No. 1821638-43-0
LUF7244, a selective allosteric modulator of K v 11.1 channels, effectively suppresses early afterdepolarizations and holds potential for anti-arrhythmia research [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | LUF7244, a selective allosteric modulator of K v 11.1 channels, effectively suppresses early afterdepolarizations and holds potential for anti-arrhythmia research [1]. |
| In vitro | LUF7244, at concentrations ranging from 0 to 10 μM, specifically targets and binds to Kv11.1 channels in HEK293 cells, thereby enhancing the IKv11.1 by preventing its inactivation in a dose-responsive manner [1]. In cardiomyocytes within the same concentration range, LUF7244 significantly shortens the action potential duration (APD) by about 50% and mitigates dofetilide-induced early afterdepolarizations (EAD) in isolated ventricular cardiomyocytes from both SR and CAVB dogs [1]. At a concentration of 10 μM, LUF7244 does not affect the currents I_KIR2.1, I_Nav1.5, I_Ca-L, and I_Ks, but it notably increases I_Kr twofold [1]. |
| In vivo | LUF7244, administered intravenously at a dosage of 2.5 mg/kg over 15 minutes, effectively reduces repolarization parameters and exhibits antiarrhythmic properties, mitigating dofetilide-induced Torsades de Pointes (TdP) arrhythmias in dogs with chronic atrioventricular block (CAVB) [1]. |
| Molecular Weight | 366.8 |
| Formula | C20H15ClN2O3 |
| Cas No. | 1821638-43-0 |
| Smiles | C(=O)(C1=CC=C(OCC(NC=2C=CC=NC2)=O)C=C1)C3=CC(Cl)=CC=C3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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