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XJB-5-131

Catalog No. T40979 CAS 866404-31-1

XJB-5-131 is a synthetic, bi-functional antioxidant specifically designed to target mitochondria for the scavenging of reactive oxygen species (ROS) and electrons, thereby acting as a radical scavenger. Additionally, it serves as an effective protector and mitigator against ionizing irradiation for cord blood mononuclear cells (CB MNCs).

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XJB-5-131, CAS 866404-31-1

Pack Size	Availability	Price/USD	Quantity
5 mg	Inquiry	$ 647.00

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Biological Description

Chemical Properties

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Description	XJB-5-131 is a synthetic, bi-functional antioxidant specifically designed to target mitochondria for the scavenging of reactive oxygen species (ROS) and electrons, thereby acting as a radical scavenger. Additionally, it serves as an effective protector and mitigator against ionizing irradiation for cord blood mononuclear cells (CB MNCs).
In vitro	XJB-5-131 mitigates hemorrhagic shock (HS)-induced activation of caspases 3 and 7, key pro-apoptotic enzymes, in the ileal mucosa, thereby reducing apoptosis and enhancing cell survival, as evidenced in mouse embryonic cells in vitro. Additionally, it serves as an effective radiation shield, particularly for colony-forming unit-granulocyte macrophage (CFU-GM), displaying significant protective and mitigative effects when administered before or after irradiation. This is demonstrated by its capacity to increase the D0 to 1.93±0.13 for CFU-GM when provided as a treatment, highlighting its potential as a versatile agent in cellular protection and survival enhancement mechanisms.
In vivo	XJB-5-131 mitigates peroxidation of cardiolipin, a key mitochondrial phospholipid, in rat ileal mucosal samples following hemorrhagic shock (HS)[1], and intravenous administration at 2 μmol/kg notably extends survival in rats experiencing severe blood loss (33.5 mL/kg), with minimal crystalloid solution volume (2.8 mL/kg) and no blood transfusion[1]. It also diminishes oxidative harm to mitochondrial DNA, upholds mitochondrial DNA quantity, halts motor function degradation and weight loss, augments neuronal preservation, and boosts mitochondrial efficiency. In a Huntington’s disease (HD) mouse model, XJB-5-131 significantly curtails disease phenotypes and enhances mitochondrial performance[2], and at a dosage of 1 mg/kg, given intraperitoneally three times weekly for up to 57 weeks, it counters weight and motor function decline[2]. Study specifics include utilization of male Sprague-Dawley rats (150 to 250 g)[1] with outcomes showing marked survival improvement (P < 0.01), and HD150KI mice for HD research[2], where chronic treatment inhibited weight reduction and elevated average body mass by 22%.

Molecular Weight	959.263
Formula	C53H80N7O9
CAS No.	866404-31-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Carlos A Macias, et al. Treatment with a novel hemigramicidin-TEMPO conjugate prolongs survival in a rat model of lethal hemorrhagic shock. Ann Surg. 2007 Feb;245(2):305-14. 2. Zhiyin Xun, et al. Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Rep. 2012 Nov 29;2(5):1137-42. 3. Julie P Goff, et al. Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells. Exp Hematol. 2013 Nov;41(11):957-66.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

XJB-5-131 866404-31-1 XJB5131 XJB 5 131 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.