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BPR1K871

Name: BPR1K871
Brand: TargetMol
SKU: T10592
Rating: 4.5 (1 reviews)

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Catalog No. T10592Cas No. 2443767-35-7

Alias DBPR114

BPR1K871, a preclinical development candidate for anti-cancer therapy [1], is a potent, selective dual inhibitor targeting FLT3 and AURKA, with IC50 values of 19 nM and 22 nM, respectively.

BPR1K871

😃Good

Catalog No. T10592Alias DBPR114Cas No. 2443767-35-7

BPR1K871, a preclinical development candidate for anti-cancer therapy [1], is a potent, selective dual inhibitor targeting FLT3 and AURKA, with IC50 values of 19 nM and 22 nM, respectively.

Pack Size	Price	Availability	Quantity
10 mg	$1,240	7-10 days
25 mg	$2,130	7-10 days

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Product Introduction

Bioactivity

Description	BPR1K871, a preclinical development candidate for anti-cancer therapy [1], is a potent, selective dual inhibitor targeting FLT3 and AURKA, with IC50 values of 19 nM and 22 nM, respectively.
Targets&IC50	FLT3:19 nM , AURKA:22 nM
In vitro	BPR1K871 demonstrates strong anti-proliferative effects on MOLM-13 and MV4-11 AML cells, achieving an EC50 of approximately 5 nM [1].
In vivo	BPR1K871, a multi-kinase inhibitor, is utilized for the treatment of acute myeloid leukemia (AML) and solid tumors [1].
Synonyms	DBPR114

Chemical Properties

Molecular Weight	526.05
Formula	C₂₅H₂₈ClN₇O₂S
Cas No.	2443767-35-7
Relative Density.	1.387 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (237.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9010 mL	9.5048 mL	19.0096 mL	95.0480 mL
5 mM	0.3802 mL	1.9010 mL	3.8019 mL	19.0096 mL
10 mM	0.1901 mL	0.9505 mL	1.9010 mL	9.5048 mL
20 mM	0.0950 mL	0.4752 mL	0.9505 mL	4.7524 mL
50 mM	0.0380 mL	0.1901 mL	0.3802 mL	1.9010 mL
100 mM	0.0190 mL	0.0950 mL	0.1901 mL	0.9505 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc