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PF 750

Name: PF 750
Brand: TargetMol
SKU: T16515
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16515Cas No. 959151-50-9

Alias ZINC27647189, UNII-7756CPP14K, PF-750

PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times.

PF 750

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Purity: 99.87%

Catalog No. T16515Alias ZINC27647189, UNII-7756CPP14K, PF-750Cas No. 959151-50-9

PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	-	In Stock
5 mg	$56	-	In Stock
10 mg	$89	-	In Stock
25 mg	$197	-	In Stock
50 mg	$313	-	In Stock
100 mg	$467	-	In Stock
200 mg	$669	-	In Stock
500 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$62	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

PF 750 AI Summary

PF 750 is a potent inhibitor of fatty acid amide hydrolase (FAAH), exhibiting an IC50 value of 16.2 nM. It demonstrates selectivity towards human FAAH over rat FAAH with a Kinact/Ki ratio selectivity of 8.0. Additionally, it effectively inhibits human recombinant FAAH, showing varying inhibition potency across different assay conditions, including both reversible and irreversible inhibition profiles. Besides its FAAH inhibitory activity, PF 750 shows notable antiviral activity by significantly reducing SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 µM, and it also inhibits SARS-CoV-2 3CL-Pro protease to a lesser extent. Moreover, PF 750 inhibits human HDAC6 by 27.72% in enzymatic assays using commercial peptide substrates. These multifaceted activities underscore its potential as a therapeutic agent targeting FAAH and exhibiting some antiviral properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times.
Targets&IC50	FAAH:16.2-595 nM
Synonyms	ZINC27647189, UNII-7756CPP14K, PF-750

Chemical Properties

Molecular Weight	345.44
Formula	C₂₂H₂₃N₃O
Cas No.	959151-50-9
Smiles	O=C(Nc1ccccc1)N1CCC(Cc2cnc3ccccc3c2)CC1
Relative Density.	1.226 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (260.54 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8949 mL	14.4743 mL	28.9486 mL	144.7429 mL
5 mM	0.5790 mL	2.8949 mL	5.7897 mL	28.9486 mL
10 mM	0.2895 mL	1.4474 mL	2.8949 mL	14.4743 mL
20 mM	0.1447 mL	0.7237 mL	1.4474 mL	7.2371 mL
50 mM	0.0579 mL	0.2895 mL	0.5790 mL	2.8949 mL
100 mM	0.0289 mL	0.1447 mL	0.2895 mL	1.4474 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc