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TargetMol | Compound Library

Anti-Neurodegenerative Disease Compound Library

Catalog No. L2620

Neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS), are incurable and debilitating conditions characterized by progressive degeneration of specific neurons within the brains of affected individuals. Neurodegenerative diseases have become an enormous economic burden that is projected to grow significantly over the next few decades in the absence of any new therapeutic interventions.

Drugs for the central nervous system, including neurodegenerative diseases, that entered clinical development, have a considerably lower probability of reaching the marketplace (7%) than the industry average across other therapeutic areas (15%), and require a longer time for development and regulatory approval (average of 12.6 years) compared with most other diseases (e.g., 6.3 years for cardiovascular and 7.5 years for gastrointestinal indications).

In this compound library, TargetMol collects 2154 compounds related to neurodegenerative diseases having therapeutic effect or acting on neurodegenerative disease-related targets.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2620

Anti-Neurodegenerative Disease Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 2154 compounds related to neurodegenerative diseases can be used for HTS or HCS;
  • Targets include AchE, NMDA, CGRP, β -secretase, γ -secretase, Dopamine receptor, Adenosine receptor, 5-HT receptor, etc.;
  • Some of them are FDA-approved;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Library Customization | TargetMol Library Composition

5-HT Receptor
AChR
Dopamine Receptor
Adrenergic Receptor
Apoptosis
Autophagy
GABA Receptor
iGluR
Endogenous Metabolite
GluR
Cholinesterase (ChE)
Histamine Receptor
Opioid Receptor
NMDAR
Beta Amyloid
PDE
ROS
Monoamine Oxidase
COX
Antibacterial
NF-κB
MAO
Potassium Channel
JNK
Reactive Oxygen Species
Serotonin Transporter
Calcium Channel
Parasite
PPAR
Gamma-secretase
Caspase
Norepinephrine
GSK-3
Sodium Channel
Cytochromes P450
Adenosine Receptor
TNF
Akt
ERK
Influenza Virus
Nrf2
Interleukin
PI3K
HIV Protease
CDK
CaMK
LRRK2
NO Synthase
p38 MAPK
Ferroptosis
BACE
Mitophagy
Beta-Secretase
Antifungal
MMP
Drug Metabolite
Transferase
Mitochondrial Metabolism
Virus Protease
Wnt/beta-catenin
DNA/RNA Synthesis
Antibiotic
Sigma receptor
Cannabinoid Receptor
P-gp
Phosphatase
mTOR
TRP/TRPV Channel
Dehydrogenase
IL Receptor
Bcl-2 Family
IκB/IKK
SARS-CoV
Src
VEGFR
Bcr-Abl
Trk receptor
Estrogen/progestogen Receptor
PKC
Sirtuin
AMPK
Phospholipase
Microtubule Associated
Imidazoline Receptor
HDAC
Melatonin Receptor
Glucosidase
PARP
GlyT
Lipoxygenase
MEK
Anti-infection
Antioxidant
c-Kit
MRP
glycosidase
TLR
CCR
PKA
Adenylyl Cyclase
P2X Receptor
Tyrosinase
HIF/HIF Prolyl-Hydroxylase
NOD-like Receptor (NLR)
OX Receptor
EGFR
FLT
Amino Acids and Derivatives
Prostaglandin Receptor
MT Receptor
JAK
MAPK
S1P Receptor
Histone Methyltransferase
LPL Receptor
Epigenetic Reader Domain
Aurora Kinase
P2Y Receptor
Estrogen Receptor/ERR
FAAH
Ras
FGFR
Histone Demethylase
STAT
NOS
ROR
AAK1
GPCR
UGT
HMG-CoA Reductase
RAAS
Carbonic Anhydrase
Retinoid Receptor
HSV
Neurokinin receptor
ABC Transporter
TGF-beta/Smad
MDM-2/p53
IGF-1R
NOD
NADPH
Casein Kinase
Glucocorticoid Receptor
S6 Kinase
p53
c-Fms
Monoamine Transporter
Antiviral
transporter
Rho
Histone Acetyltransferase
Chloride channel
PGE Synthase
HBV
c-Met/HGFR
AAK1 (AP2 associated kinase 1)
IRAK
IFNAR
Aryl Hydrocarbon Receptor
Angiotensin-converting Enzyme (ACE)
Integrin
PTEN
FXR
Epoxide Hydrolase
PERK
Nucleoside Antimetabolite/Analog
DUB
MIF
RSV
PDGFR
IAP
ATM/ATR
Cysteine Protease
HSP
Topoisomerase
Free radical scavengers
Decarboxylase
PAFR
DYRK
OCT
Raf
OXPHOS
Hydroxylase
Transaminase
FAK
CSF-1R
Antifection
CRISPR/Cas9
Guanylate cyclase
Advanced Glycation End Products
Monocarboxylate transporter
Serine/threonin kinase
Reverse Transcriptase
Acyltransferase
Gap Junction Protein
STING
CGRP Receptor
ATPase
FOXO
Stearoyl-CoA Desaturase (SCD)
CFTR
Immunology/Inflammation related
Liver X Receptor
Progesterone Receptor
Necroptosis
FOXO3
Somatostatin
Thyroid hormone receptor(THR)
Lipase
Proteasome
PSMA
ALK
c-Myc
LDL
Pyroptosis
RAR/RXR
Hexokinase
HIF
PDK
DNA Methyltransferase
Annexin A
Survivin
Prolyl Endopeptidase (PREP)
Telomerase
Aromatase
FKBP
Serine Protease
PAI-1
DNA Alkylation
LDLR
SGK
Arrestin
NR4A
REV-ERB
Lipid
Glutathione Peroxidase
Na+/Ca2+ Exchanger
Aquaporin
Reductase
Liposome
RIP kinase
ROS Kinase
Adenosine Deaminase
GRK
Neuropeptide Y Receptor
Neprilysin
NPC1L1
Orphan Receptor
SGLT
Cuproptosis
OAT
ATP Citrate Lyase
Adiponectin Receptor
Glutaminase
IDO
GluCls
CAT
Thrombin
PAD
Chk
PAK
HCN Channel
Hck
MLK
HCV Protease
Indoleamine 2,3-Dioxygenase (IDO)
Syk
Neurotensin Receptor
Glutaminyl Cyclase
Taste receptor
GTPase
MNK
ROCK
CaSR
RANKL/RANK
Cadherin
Carboxypeptidase
GST
Androgen Receptor
Bombesin Receptor
E1/E2/E3 Enzyme
NMU2R
Vitamin
BTK
NMUR

Keywords