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TargetMol | Compound Library

Anti-Neurodegenerative Disease Compound Library

Catalog No. L2620

Neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS), are incurable and debilitating conditions characterized by progressive degeneration of specific neurons within the brains of affected individuals. Neurodegenerative diseases have become an enormous economic burden that is projected to grow significantly over the next few decades in the absence of any new therapeutic interventions.

Drugs for the central nervous system, including neurodegenerative diseases, that entered clinical development, have a considerably lower probability of reaching the marketplace (7%) than the industry average across other therapeutic areas (15%), and require a longer time for development and regulatory approval (average of 12.6 years) compared with most other diseases (e.g., 6.3 years for cardiovascular and 7.5 years for gastrointestinal indications).

In this compound library, TargetMol collects 2154 compounds related to neurodegenerative diseases having therapeutic effect or acting on neurodegenerative disease-related targets.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2620

Anti-Neurodegenerative Disease Compound Library

size

  • 1 mg
  • 10 µL x 10 mM (in DMSO)
  • 20 µL x 10 mM (in DMSO)
  • 30 µL x 10 mM (in DMSO)
  • 50 µL x 10 mM (in DMSO)
  • 100 µL x 10 mM (in DMSO)
  • 250 µL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 2154 compounds related to neurodegenerative diseases can be used for HTS or HCS;
  • Targets include AchE, NMDA, CGRP, β -secretase, γ -secretase, Dopamine receptor, Adenosine receptor, 5-HT receptor, etc.;
  • Some of them are FDA-approved;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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5-HT Receptor
AChR
Dopamine Receptor
Adrenergic Receptor
Apoptosis
Autophagy
GABA Receptor
iGluR
Endogenous Metabolite
GluR
Cholinesterase (ChE)
Histamine Receptor
Opioid Receptor
NMDAR
Beta Amyloid
PDE
ROS
Monoamine Oxidase
Antibacterial
COX
NF-κB
MAO
Potassium Channel
Reactive Oxygen Species
JNK
Serotonin Transporter
Parasite
Calcium Channel
PPAR
Gamma-secretase
Caspase
GSK-3
Sodium Channel
Norepinephrine
Adenosine Receptor
Cytochromes P450
TNF
Akt
ERK
Influenza Virus
Nrf2
HIV Protease
Interleukin
PI3K
CDK
LRRK2
NO Synthase
CaMK
p38 MAPK
Ferroptosis
Mitophagy
Beta-Secretase
Antifungal
BACE
Mitochondrial Metabolism
MMP
Drug Metabolite
Transferase
Antibiotic
Cannabinoid Receptor
DNA/RNA Synthesis
Virus Protease
Wnt/beta-catenin
Sigma receptor
Phosphatase
P-gp
Adenylate cyclase
mTOR
Dehydrogenase
TRP/TRPV Channel
Bcl-2 Family
SARS-CoV
IκB/IKK
VEGFR
IL Receptor
Src
Estrogen/progestogen Receptor
Bcr-Abl
Microtubule Associated
AMPK
Phospholipase
Trk receptor
PKC
Imidazoline Receptor
PARP
Glucosidase
Melatonin Receptor
P2X Receptor
GlyT
MEK
Antioxidant
HDAC
Lipoxygenase
EGFR
PKA
JAK
Epigenetic Reader Domain
TLR
Tyrosinase
Amino Acids and Derivatives
HIF/HIF Prolyl-Hydroxylase
MRP
OX Receptor
FLT
Anti-infection
c-Kit
NOD-like Receptor (NLR)
CCR
glycosidase
Sirtuin
GPCR
NOD
Estrogen Receptor/ERR
Prostaglandin Receptor
P2Y Receptor
Ras
S1P Receptor
Histone Methyltransferase
LPL Receptor
MT Receptor
ABC Transporter
FAAH
MDM-2/p53
RAAS
AAK1
TGF-beta/Smad
NOS
PTEN
Retinoid Receptor
ROR
MAPK
UGT
Aurora Kinase
FGFR
HMG-CoA Reductase
STAT
Carbonic Anhydrase
Histone Demethylase
HSV
IGF-1R
c-Met/HGFR
Rho
Histone Acetyltransferase
IRAK
Integrin
HSP
Neurokinin receptor
Chloride channel
FXR
Aryl Hydrocarbon Receptor
Epoxide Hydrolase
p53
Angiotensin-converting Enzyme (ACE)
c-Fms
PGE Synthase
IFNAR
NADPH
Glucocorticoid Receptor
AAK1 (AP2 associated kinase 1)
Antiviral
transporter
S6 Kinase
PERK
HBV
Casein Kinase
FOXO
DYRK
Progesterone Receptor
Liver X Receptor
PAI-1
Reverse Transcriptase
Gap Junction Protein
CSF-1R
Acyltransferase
Decarboxylase
ATM/ATR
Monocarboxylate transporter
Serine/threonin kinase
Cysteine Protease
Topoisomerase
Guanylate cyclase
OXPHOS
STING
Free radical scavengers
CGRP Receptor
Immunology/Inflammation related
PAFR
DUB
RSV
Transaminase
MIF
Antifection
FAK
Advanced Glycation End Products
Necroptosis
OCT
Raf
GRK
Stearoyl-CoA Desaturase (SCD)
ATPase
Nucleoside Antimetabolite/Analog
IAP
Monoamine Transporter
PDGFR
CRISPR/Cas9
Hydroxylase
CFTR
CAT
Na+/Ca2+ Exchanger
GTPase
CaSR
HCN Channel
PAK
ALK
GST
Carboxypeptidase
Aromatase
HIF
REV-ERB
ROS Kinase
Thyroid hormone receptor(THR)
Proteasome
Taste receptor
NPC1L1
Reductase
LDLR
DNA Alkylation
Neprilysin
Adenosine Deaminase
Liposome
RAR/RXR
HCV Protease
Arrestin
Glutathione Peroxidase
Prolyl Endopeptidase (PREP)
LDL
Cadherin
GluCls
Pyroptosis
FKBP
MLK
Lipase
Serine Protease
Hexokinase
Chk
Orphan Receptor
OAT
MNK
Syk
Glutaminyl Cyclase
Neurotensin Receptor
Glutaminase
RIP kinase
Somatostatin
PAD
Indoleamine 2,3-Dioxygenase (IDO)
Androgen Receptor
Survivin
Aquaporin
Cuproptosis
Hck
ROCK
RANKL/RANK
IDO
Annexin A
Neuropeptide Y Receptor
Bombesin Receptor
Telomerase
SGLT
Lipid
PSMA
FOXO3
PDK
SGK
DNA Methyltransferase
Thrombin
NR4A
E1/E2/E3 Enzyme
Adiponectin Receptor
ATP Citrate Lyase
BTK
NMU2R
Vitamin
NMUR

Keywords