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TargetMol | Compound Library

Anti-Neurodegenerative Disease Compound Library

Catalog No. L2620

Neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS), are incurable and debilitating conditions characterized by progressive degeneration of specific neurons within the brains of affected individuals. Neurodegenerative diseases have become an enormous economic burden that is projected to grow significantly over the next few decades in the absence of any new therapeutic interventions. Drugs for the central nervous system, including neurodegenerative diseases, that entered clinical development, have a considerably lower probability of reaching the marketplace (7%) than the industry average across other therapeutic areas (15%), and require a longer time for development and regulatory approval (average of 12.6 years) compared with most other diseases (e.g., 6.3 years for cardiovascular and 7.5 years for gastrointestinal indications). In this compound library, TargetMol collects 2154 compounds related to neurodegenerative diseases having therapeutic effect or acting on neurodegenerative disease-related targets.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2620

Anti-Neurodegenerative Disease Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 2154 compounds related to neurodegenerative diseases can be used for HTS or HCS;
  • Targets include AchE, NMDA, CGRP, β -secretase, γ -secretase, Dopamine receptor, Adenosine receptor, 5-HT receptor, etc.;
  • Some of them are FDA-approved;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Library Customization | TargetMol Library Composition

5-HT Receptor
AChR
Dopamine Receptor
Adrenergic Receptor
GABA Receptor
Apoptosis
Autophagy
GluR
Cholinesterase (ChE)
Histamine Receptor
Endogenous Metabolite
Opioid Receptor
NMDAR
PDE
iGluR
Beta Amyloid
COX
MAO
Monoamine Oxidase
JNK
Gamma-secretase
Serotonin Transporter
Antibacterial
NF-κB
Reactive Oxygen Species
GSK-3
Norepinephrine
Potassium Channel
PPAR
Adenosine Receptor
Sodium Channel
Caspase
Cytochromes P450
Calcium Channel
Parasite
HIV Protease
Nrf2
Influenza Virus
CaMK
LRRK2
TNF
BACE
Mitophagy
CDK
Transferase
Ferroptosis
Antifungal
ERK
Cannabinoid Receptor
Dehydrogenase
Phosphatase
Mitochondrial Metabolism
Beta-Secretase
Antibiotic
Src
TRP/TRPV Channel
IL Receptor
Akt
p38 MAPK
Estrogen/progestogen Receptor
Bcr-Abl
P-gp
NO Synthase
PI3K
Virus Protease
MMP
DNA/RNA Synthesis
Phospholipase
Sigma receptor
Imidazoline Receptor
Antioxidant
Wnt/beta-catenin
PARP
GlyT
ROS
Bcl-2 Family
IκB/IKK
AMPK
Microtubule Associated
Adenylyl Cyclase
MRP
VEGFR
PKC
Drug Metabolite
MT Receptor
P2X Receptor
OX Receptor
Lipoxygenase
Interleukin
Sirtuin
HDAC
MEK
FLT
c-Kit
LPL Receptor
P2Y Receptor
Melatonin Receptor
PKA
AAK1
FAAH
Aurora Kinase
Epigenetic Reader Domain
mTOR
EGFR
SARS-CoV
Anti-infection
S1P Receptor
NOS
Carbonic Anhydrase
ROR
Histone Methyltransferase
RAAS
Estrogen Receptor/ERR
ABC Transporter
Glucosidase
CCR
IGF-1R
MAPK
Prostaglandin Receptor
Trk receptor
Retinoid Receptor
FGFR
Neurokinin receptor
HMG-CoA Reductase
Tyrosinase
HIF/HIF Prolyl-Hydroxylase
GPCR
Chloride channel
Amino Acids and Derivatives
Histone Demethylase
NADPH
Rho
Glucocorticoid Receptor
JAK
HSV
Epoxide Hydrolase
TGF-beta/Smad
Antiviral
Histone Acetyltransferase
Casein Kinase
c-Fms
NOD
S6 Kinase
p53
Advanced Glycation End Products
Transaminase
Integrin
c-Met/HGFR
IFNAR
DYRK
Progesterone Receptor
HBV
Nucleoside Antimetabolite/Analog
Cysteine Protease
FXR
Aryl Hydrocarbon Receptor
CSF-1R
Topoisomerase
UGT
PAFR
Raf
Antifection
Monoamine Transporter
Guanylate cyclase
Stearoyl-CoA Desaturase (SCD)
DUB
PGE Synthase
Acyltransferase
STING
Free radical scavengers
transporter
Decarboxylase
RSV
ATM/ATR
Reverse Transcriptase
CRISPR/Cas9
CGRP Receptor
Gap Junction Protein
Ras
FAK
NOD-like Receptor (NLR)
FOXO3
Proteasome
ATPase
CAT
NPC1L1
Monocarboxylate transporter
RAR/RXR
HCV Protease
Glutaminyl Cyclase
Arrestin
Na+/Ca2+ Exchanger
PERK
Glutathione Peroxidase
GTPase
OCT
Hck
Serine/threonin kinase
Liver X Receptor
ROCK
RANKL/RANK
IAP
Immunology/Inflammation related
Annexin A
E1/E2/E3 Enzyme
Adiponectin Receptor
LDL
GRK
Hexokinase
HCN Channel
Neuropeptide Y Receptor
DNA Alkylation
PDGFR
Bombesin Receptor
PAK
Somatostatin
Chk
PAD
Indoleamine 2,3-Dioxygenase (IDO)
Androgen Receptor
Telomerase
SGLT
OAT
HSP
TLR
GluCls
PAI-1
ALK
Neprilysin
GST
STAT
Aromatase
PDK
Hydroxylase
HIF
Adenosine Deaminase
SGK
NMU2R
Syk
DNA Methyltransferase
IRAK
Thrombin
MLK
Vitamin
BTK

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