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TargetMol | Compound Library

Anti-Neurodegenerative Disease Compound Library

Catalog No. L2620

Neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS), are incurable and debilitating conditions characterized by progressive degeneration of specific neurons within the brains of affected individuals. Neurodegenerative diseases have become an enormous economic burden that is projected to grow significantly over the next few decades in the absence of any new therapeutic interventions. Drugs for the central nervous system, including neurodegenerative diseases, that entered clinical development, have a considerably lower probability of reaching the marketplace (7%) than the industry average across other therapeutic areas (15%), and require a longer time for development and regulatory approval (average of 12.6 years) compared with most other diseases (e.g., 6.3 years for cardiovascular and 7.5 years for gastrointestinal indications). In this compound library, TargetMol collects 2154 compounds related to neurodegenerative diseases having therapeutic effect or acting on neurodegenerative disease-related targets.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2620

Anti-Neurodegenerative Disease Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 2154 compounds related to neurodegenerative diseases can be used for HTS or HCS;
  • Targets include AchE, NMDA, CGRP, β -secretase, γ -secretase, Dopamine receptor, Adenosine receptor, 5-HT receptor, etc.;
  • Some of them are FDA-approved;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Library Customization | TargetMol Library Composition

5-HT Receptor
AChR
Dopamine Receptor
Adrenergic Receptor
Apoptosis
Autophagy
GABA Receptor
Endogenous Metabolite
GluR
iGluR
Cholinesterase (ChE)
Histamine Receptor
Opioid Receptor
NMDAR
PDE
Beta Amyloid
Monoamine Oxidase
COX
MAO
Antibacterial
Reactive Oxygen Species
JNK
Serotonin Transporter
NF-κB
Potassium Channel
Gamma-secretase
Parasite
GSK-3
Calcium Channel
Norepinephrine
PPAR
Sodium Channel
Adenosine Receptor
Caspase
Cytochromes P450
TNF
ERK
Nrf2
Influenza Virus
HIV Protease
CDK
CaMK
Akt
LRRK2
Ferroptosis
BACE
Mitophagy
Beta-Secretase
Transferase
Antifungal
Sigma receptor
NO Synthase
PI3K
Phosphatase
Virus Protease
Interleukin
Cannabinoid Receptor
Antibiotic
Dehydrogenase
Mitochondrial Metabolism
Src
p38 MAPK
VEGFR
TRP/TRPV Channel
IL Receptor
MMP
Estrogen/progestogen Receptor
Bcr-Abl
Drug Metabolite
DNA/RNA Synthesis
P-gp
Bcl-2 Family
IκB/IKK
mTOR
SARS-CoV
Phospholipase
Imidazoline Receptor
Antioxidant
Melatonin Receptor
Wnt/beta-catenin
PARP
GlyT
Glucosidase
ROS
Lipoxygenase
Sirtuin
HDAC
AMPK
Anti-infection
Microtubule Associated
Adenylyl Cyclase
MRP
PKC
P2X Receptor
OX Receptor
EGFR
MEK
FLT
c-Kit
Amino Acids and Derivatives
LPL Receptor
P2Y Receptor
PKA
Estrogen Receptor/ERR
AAK1
MT Receptor
FAAH
Aurora Kinase
Epigenetic Reader Domain
MAPK
Prostaglandin Receptor
Trk receptor
Tyrosinase
HIF/HIF Prolyl-Hydroxylase
S1P Receptor
GPCR
NOS
Carbonic Anhydrase
ROR
Histone Methyltransferase
RAAS
AAK1 (AP2 associated kinase 1)
ABC Transporter
HSV
CCR
IGF-1R
Retinoid Receptor
FGFR
Neurokinin receptor
NOD
Ras
HMG-CoA Reductase
NOD-like Receptor (NLR)
Chloride channel
c-Met/HGFR
NADPH
Histone Demethylase
Rho
FXR
Glucocorticoid Receptor
Monoamine Transporter
JAK
PTEN
Epoxide Hydrolase
TGF-beta/Smad
PGE Synthase
Antiviral
Histone Acetyltransferase
transporter
Casein Kinase
c-Fms
MDM-2/p53
S6 Kinase
p53
Advanced Glycation End Products
Transaminase
Monocarboxylate transporter
Integrin
IFNAR
DYRK
MIF
Progesterone Receptor
OCT
HBV
Nucleoside Antimetabolite/Analog
Cysteine Protease
Aryl Hydrocarbon Receptor
CSF-1R
Topoisomerase
UGT
PAFR
Raf
Antifection
Guanylate cyclase
PDGFR
Stearoyl-CoA Desaturase (SCD)
Angiotensin-converting Enzyme (ACE)
DUB
OXPHOS
Acyltransferase
STING
Free radical scavengers
Decarboxylase
RSV
ATM/ATR
Reverse Transcriptase
CRISPR/Cas9
Hydroxylase
CGRP Receptor
Gap Junction Protein
FAK
FOXO3
Thyroid hormone receptor(THR)
Proteasome
ATPase
CAT
NPC1L1
RAR/RXR
HCV Protease
Glutaminyl Cyclase
Na+/Ca2+ Exchanger
Reductase
Arrestin
PERK
Necroptosis
Glutathione Peroxidase
GTPase
c-Myc
CaSR
Serine Protease
Hck
Serine/threonin kinase
Liver X Receptor
Neurotensin Receptor
Glutaminase
ROCK
NR4A
RANKL/RANK
IDO
IAP
Immunology/Inflammation related
Prolyl Endopeptidase (PREP)
Annexin A
E1/E2/E3 Enzyme
Adiponectin Receptor
LDL
GRK
Hexokinase
HCN Channel
Neuropeptide Y Receptor
DNA Alkylation
Bombesin Receptor
PAK
Somatostatin
Chk
PAD
Indoleamine 2,3-Dioxygenase (IDO)
Androgen Receptor
Telomerase
SGLT
ATP Citrate Lyase
OAT
MNK
HSP
TLR
GluCls
PAI-1
Pyroptosis
ALK
Neprilysin
GST
STAT
Aromatase
PDK
HIF
Adenosine Deaminase
Cuproptosis
SGK
REV-ERB
Syk
DNA Methyltransferase
IRAK
Thrombin
Liposome
ROS Kinase
CFTR
MLK
Vitamin
BTK
NMU2R
NMUR

Keywords