BACE1 Protein, Mouse, Recombinant (His)

Catalog No. TMPY-00678

BACE1 Protein, Mouse, Recombinant (His) is expressed in HEK293 Cells. The accession number is P56818.

BACE1 Protein, Mouse, Recombinant (His)

Catalog No. TMPY-00678

BACE1 Protein, Mouse, Recombinant (His) is expressed in HEK293 Cells. The accession number is P56818.

Pack Size	Price	USA Warehouse	Global Warehouse
5 μg	$68	7-10 days	7-10 days
10 μg	$108	7-10 days	7-10 days
20 μg	$178	7-10 days	7-10 days
50 μg	$359	7-10 days	7-10 days
100 μg	$696	7-10 days	7-10 days
200 μg	$1,060	7-10 days	7-10 days
500 μg	$2,230	7-10 days	7-10 days
1 mg	$4,530	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse [1-2 days] Global Warehouse [5-7 days]

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Product Information

Biological Activity	Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK(Dpn)RR-NH2. The specific activity is > 3 pmol/min/µg. (QC Test)
Description	BACE1 Protein, Mouse, Recombinant (His) is expressed in HEK293 Cells. The accession number is P56818.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P56818
Synonyms	β-site APP-cleaving enzyme 1,C76936,beta-site APP-cleaving enzyme 1
Construction	Thr22-Thr457
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	49.49 kDa (Predicted); 60-70 kDa (Reducing conditions due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	The beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) initiates the generation of amyloid-β (Aβ), and the amyloid cascade leading to amyloid plaque deposition, neurodegeneration, and dementia in Alzheimer's disease (AD). Clinical failures of anti-Aβ therapies in dementia stages suggest that treatment has to start in the early, asymptomatic disease states.