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Multi-kinase-IN-6

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Catalog No. T81740

Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. It exhibits antiproliferative effects on MCF7, HCT116, and EKVX cancer cell lines with IC50s of 3.36 μM, 1.40 μM, and 3.49 μM, respectively. Additionally, Multi-kinase-IN-6 induces cell cycle arrest at the G1/S and G1 phases in MCF7 and HCT116 cells, respectively, and effectively triggers apoptosis [1].

Multi-kinase-IN-6

Multi-kinase-IN-6

😃Good
Catalog No. T81740
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. It exhibits antiproliferative effects on MCF7, HCT116, and EKVX cancer cell lines with IC50s of 3.36 μM, 1.40 μM, and 3.49 μM, respectively. Additionally, Multi-kinase-IN-6 induces cell cycle arrest at the G1/S and G1 phases in MCF7 and HCT116 cells, respectively, and effectively triggers apoptosis [1].
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Bioactivity
Description
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. It exhibits antiproliferative effects on MCF7, HCT116, and EKVX cancer cell lines with IC50s of 3.36 μM, 1.40 μM, and 3.49 μM, respectively. Additionally, Multi-kinase-IN-6 induces cell cycle arrest at the G1/S and G1 phases in MCF7 and HCT116 cells, respectively, and effectively triggers apoptosis [1].
Targets&IC50
TrkA:0.33 μM, Chk1:0.15 μM, FLT3:0.34 μM, c-Kit:0.05 μM, PIM1:0.42 μM, CK2:0.09 μM, EGFR:0.1 μM, CDK2:0.71 μM, ROS1:0.75 μM, RET:0.53 μM, ALK2:0.03 μM
In vitro
MK2-IN-5 at concentrations of 5-10 μM for 2 hours inhibits the expression of connective tissue growth factor and type I collagen induced by TGF-b1 in human scar keloid fibroblasts [3].
In vivo
MK2-IN-5 (2 mg/kg, intraperitoneal injection, single dose) reduces the phosphorylation of HSP25 in ventilator-induced lung injury models [2].
Animal Research
s
Chemical Properties
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

TrkreceptorTrk receptor
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