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2-(1H-Indol-3-yl)ethan-1-ol

Name: 2-(1H-Indol-3-yl)ethan-1-ol
Brand: TargetMol
SKU: T4876
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4876Cas No. 526-55-6

Alias Tryptophol, Indole-3-ethanol, 3-(2-Hydroxyethyl)indole

2-(1H-Indol-3-yl)ethan-1-ol (3-(2-Hydroxyethyl)indole) is a metabolite formed in the liver after disulfiram treatment that induces sleep in humans. It is also a secondary product of alcoholic fermentation.

2-(1H-Indol-3-yl)ethan-1-ol

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Purity: 99.84%

Catalog No. T4876Alias Tryptophol, Indole-3-ethanol, 3-(2-Hydroxyethyl)indoleCas No. 526-55-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

2-(1H-Indol-3-yl)ethan-1-ol AI Summary

2-(1H-Indol-3-yl)ethan-1-ol exhibits a variety of biological activities and physicochemical properties. It has a low apparent permeability coefficient through an artificial membrane in the presence of an unstirred water layer, as indicated by a LogP app of -4.72, and a partition coefficient (log P) of 1.54, suggesting moderate lipophilicity. The compound shows antioxidant activity, with a DPPH radical scavenging activity of 52.0% at 300 µM after 48 hours. Bioactivity assays reveal varying potencies for 2-(1H-Indol-3-yl)ethan-1-ol: - Delayed death inhibitors of malarial parasite plastid: 3696.4 nM - GLP-1 Receptor Inverse Agonists: 31622.8 nM - BRCA1 expression activators: 316.2 nM - Vaccinia Orthopoxvirus inhibitors: 4466.8 nM - Foot and Mouth Disease Virus antivirals: 1584.9 nM The compound exhibits antifungal activity against both Leptosphaeria maculans and Cryphonectria parasitica, with significant mycelial growth inhibition at concentrations of 0.2 mM (16.0%) and 0.5 mM (29.0%) after 5 days of light exposure, as well as demonstrating an increasing inhibitory zone diameter with higher concentrations over 7 days. 2-(1H-Indol-3-yl)ethan-1-ol also shows cytotoxicity against various human cell lines, including U251, IN1472, U87, IN1528, and IN1760, with EC50 values ranging from 580,000.0 nM to 4,570,000.0 nM as assessed by the SRB assay after 72 hours. Additionally, it has anti-inflammatory activity against human HaCaT cells, demonstrating an IC50 value of 6550.0 nM in inhibiting UVB irradiation-induced PGE2 production after 2 hours, as measured by ELISA..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2-(1H-Indol-3-yl)ethan-1-ol (3-(2-Hydroxyethyl)indole) is a metabolite formed in the liver after disulfiram treatment that induces sleep in humans. It is also a secondary product of alcoholic fermentation.
Synonyms	Tryptophol, Indole-3-ethanol, 3-(2-Hydroxyethyl)indole

Chemical Properties

Molecular Weight	161.20
Formula	C₁₀H₁₁NO
Cas No.	526-55-6
Smiles	OCCC1=CNC2=CC=CC=C12
Relative Density.	1.219 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1550.87 mM), Sonication is recommended.

Methanol: 100.00 mg/mL (620.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (15.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Methanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.2035 mL	31.0174 mL	62.0347 mL	310.1737 mL
5 mM	1.2407 mL	6.2035 mL	12.4069 mL	62.0347 mL
10 mM	0.6203 mL	3.1017 mL	6.2035 mL	31.0174 mL
20 mM	0.3102 mL	1.5509 mL	3.1017 mL	15.5087 mL
50 mM	0.1241 mL	0.6203 mL	1.2407 mL	6.2035 mL
100 mM	0.0620 mL	0.3102 mL	0.6203 mL	3.1017 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc