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Anti-Angiopoietin-1 Antibody (7M254)
🥰Excellent
Catalog No. TMAY-02621
Anti-Angiopoietin-1 Antibody (7M254) is a Mouse antibody targeting Angiopoietin-1. Anti-Angiopoietin-1 Antibody (7M254) can be used in ELISA.
Anti-Angiopoietin-1 Antibody (7M254)
Anti-Angiopoietin-1 Antibody (7M254)
🥰Excellent
Catalog No. TMAY-02621
Anti-Angiopoietin-1 Antibody (7M254) is a Mouse antibody targeting Angiopoietin-1. Anti-Angiopoietin-1 Antibody (7M254) can be used in ELISA.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Angiopoietin-1 Antibody (7M254) is a Mouse antibody targeting Angiopoietin-1. Anti-Angiopoietin-1 Antibody (7M254) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG2a |
| Clone | 7M254 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Angiopoietin-1/ANGPT1 (rh Angiopoietin-1/ANGPT1; TMPY-05435; NP_001137.2; Met1-Leu261 and Arg277-Phe498). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of TIE2 in blood vessels is linked to vascular leak, inflammation, and metastasis. Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-function mutations in the angiopoietin (ANGPT) receptor TEK in families with PCG and showed that ANGPT/TEK signaling is essential for SC development. A role for the major ANGPT ligands in the development of the aqueous outflow pathway. We determined that ANGPT1 is essential for SC development, and that Angpt1-knockout mice form a severely hypomorphic canal with elevated intraocular pressure. By linking ANGPT1 with PCG, these results highlight the importance of ANGPT/TEK signaling in glaucoma pathogenesis and identify a candidate target for therapeutic development. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Angiopoietin-1/ANGPT1 Protein (TMPY-05435) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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