This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Ferroptocide
Catalog No. T83871 CAS
2505218-38-0
Ferroptocide, a thioredoxin (Trx) inhibitor and pleuromutilin derivative, exhibits inhibitory activity against Trx in ES-2 ovarian cancer cells at a concentration of 20 µM and demonstrates cytotoxicity towards these cells with an IC50 of 1.6 µM. At a dosage of 5 µM, it induces ferroptosis in ES-2 cells, which is mitigatable by the iron chelator deferoxamine (DFO), the antioxidant Trolox, or the ferroptosis inhibitor ferrostatin-1. Furthermore, it effectively reduces tumor volume in a 4T1 murine mammary carcinoma model with immunocompetent mice, but not in immunodeficient mice, when administered at 50 mg/kg bi-weekly.
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Ferroptocide, a thioredoxin (Trx) inhibitor and pleuromutilin derivative, exhibits inhibitory activity against Trx in ES-2 ovarian cancer cells at a concentration of 20 µM and demonstrates cytotoxicity towards these cells with an IC50 of 1.6 µM. At a dosage of 5 µM, it induces ferroptosis in ES-2 cells, which is mitigatable by the iron chelator deferoxamine (DFO), the antioxidant Trolox, or the ferroptosis inhibitor ferrostatin-1. Furthermore, it effectively reduces tumor volume in a 4T1 murine mammary carcinoma model with immunocompetent mice, but not in immunodeficient mice, when administered at 50 mg/kg bi-weekly.
Molecular Weight
586.08
Formula
C30H36ClN3O7
CAS No.
2505218-38-0
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Ethanol: Soluble
Methanol: Soluble
DMSO: Soluble
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.