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CHK1-IN-3

Name: CHK1-IN-3
Brand: TargetMol
SKU: T10791
Price: 181 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10791Cas No. 2097252-39-4

CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).

CHK1-IN-3

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Purity: 98.78%

Catalog No. T10791Cas No. 2097252-39-4

CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$181	In Stock	In Stock
2 mg	$257	In Stock	In Stock
5 mg	$413	In Stock	In Stock
10 mg	$621	In Stock	In Stock
25 mg	$965	In Stock	In Stock
50 mg	$1,280	In Stock	In Stock
100 mg	$1,750	In Stock	In Stock
200 mg	$2,360	-	In Stock
1 mL x 10 mM (in DMSO)	$469	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.78%

ee:100%

Appearance:Solid

Color:White

Resource Download

COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).
Targets&IC50	Chk1:0.4 nM
In vitro	CHK1-IN-3 displays a low affinity for hERG (IC50 > 40 µM). CHK1-IN-3 effectively inhibits the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 µM)[1].
In vivo	In the Z-138 cell inoculated xenograft model, CHK1-IN-3 significantly suppresses the tumor growth as a single agent with bodyweight unaffected[1].

Chemical Properties

Molecular Weight	405.46
Formula	C₂₀H₂₃N₉O
Cas No.	2097252-39-4
Smiles	N(C)C=1C(=CN=C(NC=2C=C(O[C@@H]3CCCNC3)C(C#N)=NC2)N1)C4=CN(C)N=C4
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (135.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4663 mL	12.3317 mL	24.6633 mL	123.3167 mL
5 mM	0.4933 mL	2.4663 mL	4.9327 mL	24.6633 mL
10 mM	0.2466 mL	1.2332 mL	2.4663 mL	12.3317 mL
20 mM	0.1233 mL	0.6166 mL	1.2332 mL	6.1658 mL
50 mM	0.0493 mL	0.2466 mL	0.4933 mL	2.4663 mL
100 mM	0.0247 mL	0.1233 mL	0.2466 mL	1.2332 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc