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CHK1-IN-3

🥰Excellent
Catalog No. T10791Cas No. 2097252-39-4

CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).

CHK1-IN-3

CHK1-IN-3

🥰Excellent
Purity: 98.78%
Catalog No. T10791Cas No. 2097252-39-4
CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$181In StockIn Stock
2 mg$257In StockIn Stock
5 mg$413In StockIn Stock
10 mg$621In StockIn Stock
25 mg$965In StockIn Stock
50 mg$1,280In StockIn Stock
100 mg$1,750In StockIn Stock
200 mg$2,360-In Stock
1 mL x 10 mM (in DMSO)$469In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:98.78%
ee:100%
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COA LCMS HNMR CSFC

Product Introduction

Bioactivity
Description
CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).
Targets&IC50
Chk1:0.4 nM
In vitro
CHK1-IN-3 displays a low affinity for hERG (IC50 > 40 µM). CHK1-IN-3 effectively inhibits the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 µM)[1].
In vivo
In the Z-138 cell inoculated xenograft model, CHK1-IN-3 significantly suppresses the tumor growth as a single agent with bodyweight unaffected[1].
Chemical Properties
Molecular Weight405.46
FormulaC20H23N9O
Cas No.2097252-39-4
SmilesN(C)C=1C(=CN=C(NC=2C=C(O[C@@H]3CCCNC3)C(C#N)=NC2)N1)C4=CN(C)N=C4
Relative Density.1.41 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (135.65 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4663 mL12.3317 mL24.6633 mL123.3167 mL
5 mM0.4933 mL2.4663 mL4.9327 mL24.6633 mL
10 mM0.2466 mL1.2332 mL2.4663 mL12.3317 mL
20 mM0.1233 mL0.6166 mL1.2332 mL6.1658 mL
50 mM0.0493 mL0.2466 mL0.4933 mL2.4663 mL
100 mM0.0247 mL0.1233 mL0.2466 mL1.2332 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CHK1-IN-3CHK-1-IN-3CHK1IN3CHK1 IN 3Chk1
Related Tags: buy CHK1-IN-3 | purchase CHK1-IN-3 | CHK1-IN-3 cost | order CHK1-IN-3 | CHK1-IN-3 chemical structure | CHK1-IN-3 in vivo | CHK1-IN-3 in vitro | CHK1-IN-3 formula | CHK1-IN-3 molecular weight
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