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Prednisolone disodium phosphate (Synonyms: Prednisolone phosphate sodium, Prednisolone 21-phosphate disodium)

Name: Prednisolone disodium phosphate
Brand: TargetMol
SKU: T0208
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T0208 Copy Product Info

Purity: 99.16%

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Prednisolone disodium phosphate, a synthetic glucocorticoid, has immunomodulating and anti-inflammatory properties.

Prednisolone disodium phosphate

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Catalog No. T0208

Synonyms Prednisolone phosphate sodium, Prednisolone 21-phosphate disodium

Prednisolone disodium phosphate, a synthetic glucocorticoid, has immunomodulating and anti-inflammatory properties.

Cas No. 125-02-0

Pack Size	Price	USA Stock	Global Stock	Quantity
100 mg	$35	In Stock	In Stock
200 mg	$48	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.16%

Appearance:Solid

Color:White

Resource Download

COA HNMR MS HPLC

Product Introduction

Prednisolone disodium phosphate AI Summary

Prednisolone disodium phosphate has demonstrated antiviral activity against SARS-CoV-2, exhibiting variable efficacy across different experimental assays. It showed a 7.31% inhibition rate in preventing induced cytotoxicity in Caco-2 cells at a concentration of 10 µM after 48 hours. In another assay with HRCE cells infected with the SARS-CoV-2 (USA-WA1/2020 strain) at MOI 0.4 after 96 hours, the compound recorded a low hit score of 0.07703, indicating limited effectiveness. Additionally, Prednisolone disodium phosphate displayed inhibition of the SARS-CoV-2 3CL-Pro protease with a 7.126% inhibition rate at 20 µM, measured by FRET response. However, it also showed negligible inhibition (-0.03%) of SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM after 48 hours. These results suggest that while Prednisolone disodium phosphate has some antiviral properties, its efficacy may be limited and variable depending on the assay conditions and cell lines used..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Prednisolone disodium phosphate, a synthetic glucocorticoid, has immunomodulating and anti-inflammatory properties.
Synonyms	Prednisolone phosphate sodium, Prednisolone 21-phosphate disodium

Chemical Properties

Molecular Weight	484.39
Formula	C₂₁H₂₇Na₂O₈P
Cas No.	125-02-0
Smiles	[Na+].[Na+].C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)COP([O-])([O-])=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 1 mg/mL (2.06 mM), Sonication is recommended.

H2O: 100 mg/mL (206.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0645 mL	10.3223 mL	20.6445 mL	103.2226 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.4129 mL	2.0645 mL	4.1289 mL	20.6445 mL
10 mM	0.2064 mL	1.0322 mL	2.0645 mL	10.3223 mL
20 mM	0.1032 mL	0.5161 mL	1.0322 mL	5.1611 mL
50 mM	0.0413 mL	0.2064 mL	0.4129 mL	2.0645 mL
100 mM	0.0206 mL	0.1032 mL	0.2064 mL	1.0322 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Prednisolone disodium PhosphatePrednisolone disodiumPrednisoloneInhibitorinhibitGlucocorticoidReceptorGlucocorticoid Receptor

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