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(S)-STX-478

Name: (S)-STX-478
Brand: TargetMol
SKU: T78211L
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78211LCas No. 2883540-91-6

Alias (S)-STX478

(S)-STX-478 is the S isomer of STX-478. STX-478 is a PI3Kα inhibitor that crosses the blood-brain barrier with oral activity, has anti-cancer properties, and inhibits tumor growth. It is suitable for studying breast cancer and other cancers.

(S)-STX-478

🥰Excellent

Catalog No. T78211LAlias (S)-STX478Cas No. 2883540-91-6

Pack Size	Price	Availability
1 mg	$74	In Stock
5 mg	$163	In Stock
10 mg	$245	In Stock

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Product Introduction

Bioactivity

Description	(S)-STX-478 is the S isomer of STX-478. STX-478 is a PI3Kα inhibitor that crosses the blood-brain barrier with oral activity, has anti-cancer properties, and inhibits tumor growth. It is suitable for studying breast cancer and other cancers.
In vitro	STX-478 is a potent and selective inhibitor of all kinase domain mutant forms of PI3Kα found in cancer, with KD and IC50 values of H1047R and WT PI3Kα = 4.7 nmol/L (KD), respectively. 9.4 nmol/L (IC50) and 70 nmol/L (KD) 131 nmol/L (IC50). [1]
In vivo	Treatment with STX-478 (100 mg/kg) produced powerful antitumor efficacy against PI3Kα mutant tumors in mice without metabolic dysregulation. [1]
Synonyms	(S)-STX478

Chemical Properties

Molecular Weight	401.29
Formula	C₁₆H₁₂F₅N₅O₂
Cas No.	2883540-91-6
Smiles	[C@@H](NC(NC=1C=NC(N)=NC1)=O)([C@](F)(F)F)C2=C(C)C=3C(O2)=C(F)C=C(F)C3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (199.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4920 mL	12.4598 mL	24.9196 mL	124.5982 mL
5 mM	0.4984 mL	2.4920 mL	4.9839 mL	24.9196 mL
10 mM	0.2492 mL	1.2460 mL	2.4920 mL	12.4598 mL
20 mM	0.1246 mL	0.6230 mL	1.2460 mL	6.2299 mL
50 mM	0.0498 mL	0.2492 mL	0.4984 mL	2.4920 mL
100 mM	0.0249 mL	0.1246 mL	0.2492 mL	1.2460 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc