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(S)-STX-478

Name: (S)-STX-478
Brand: TargetMol
SKU: T78211L
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78211LCas No. 2883540-91-6

Alias (S)-STX478

(S)-STX-478 is the S isomer of STX-478. STX-478 is a PI3Kα inhibitor that crosses the blood-brain barrier with oral activity, has anti-cancer properties, and inhibits tumor growth. It is suitable for studying breast cancer and other cancers.

(S)-STX-478

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Catalog No. T78211LAlias (S)-STX478Cas No. 2883540-91-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$74	-	In Stock
5 mg	$163	-	In Stock
10 mg	$245	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	(S)-STX-478 is the S isomer of STX-478. STX-478 is a PI3Kα inhibitor that crosses the blood-brain barrier with oral activity, has anti-cancer properties, and inhibits tumor growth. It is suitable for studying breast cancer and other cancers.
In vitro	STX-478 is a potent and selective inhibitor of all kinase domain mutant forms of PI3Kα found in cancer, with KD and IC50 values of H1047R and WT PI3Kα = 4.7 nmol/L (KD), respectively. 9.4 nmol/L (IC50) and 70 nmol/L (KD) 131 nmol/L (IC50). [1]
In vivo	Treatment with STX-478 (100 mg/kg) produced powerful antitumor efficacy against PI3Kα mutant tumors in mice without metabolic dysregulation. [1]
Synonyms	(S)-STX478

Chemical Properties

Molecular Weight	401.29
Formula	C₁₆H₁₂F₅N₅O₂
Cas No.	2883540-91-6
Smiles	[C@@H](NC(NC=1C=NC(N)=NC1)=O)([C@](F)(F)F)C2=C(C)C=3C(O2)=C(F)C=C(F)C3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (199.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4920 mL	12.4598 mL	24.9196 mL	124.5982 mL
5 mM	0.4984 mL	2.4920 mL	4.9839 mL	24.9196 mL
10 mM	0.2492 mL	1.2460 mL	2.4920 mL	12.4598 mL
20 mM	0.1246 mL	0.6230 mL	1.2460 mL	6.2299 mL
50 mM	0.0498 mL	0.2492 mL	0.4984 mL	2.4920 mL
100 mM	0.0249 mL	0.1246 mL	0.2492 mL	1.2460 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc